About: The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response
Creator	Malathi, Krishnamurthy Ezelle, Heather Hassel, Bret
source	Medline; PMC
abstract	The interferon (IFN)-regulated endoribonuclease RNase-L is involved in multiple aspects of the antimicrobial innate immune response. It is the terminal component of an RNA cleavage pathway in which dsRNA induces the production of RNase-L-activating 2-5A by the 2′-5′-oligoadenylate synthetase. The active nuclease then cleaves ssRNAs, both cellular and viral, leading to downregulation of their expression and the generation of small RNAs capable of activating retinoic acid-inducible gene-I (RIG-I)-like receptors or the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome. This leads to IFNβ expression and IL-1β activation respectively, in addition to broader effects on immune cell function. RNase-L is also one of a growing number of innate immune components that interact with the cell cytoskeleton. It can bind to several cytoskeletal proteins, including filamin A, an actin-binding protein that collaborates with RNase-L to maintain the cellular barrier to viral entry. This antiviral activity is independent of catalytic function, a unique mechanism for RNase-L. We also describe here the interaction of RNase-L with the E3 ubiquitin ligase and scaffolding protein, ligand of nump protein X (LNX), a regulator of tight junction proteins. In order to better understand the significance and context of these novel binding partners in the antimicrobial response, other innate immune protein interactions with the cytoskeleton are also discussed.
has issue date	2016-01-08(xsd:dateTime)
bibo:doi	10.3390/ijms17010074
bibo:pmid	26760998
has license	cc-by
sha1sum (hex)	3f21f365d6a8983fd6cf0406c66d2785d0c3a138
schema:url	https://doi.org/10.3390/ijms17010074
resource representing a document's title	The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response
has PubMed Central identifier	PMC4730318
has PubMed identifier	26760998
schema:publication	Int J Mol Sci
resource representing a document's body	covid:3f21f365d6a8983fd6cf0406c66d2785d0c3a138#body_text
is schema:about of	named entity 'IMMUNITY' named entity 'RESPONSE' named entity 'ASSOCIATED' named entity 'ROLES' named entity 'nump' named entity 'viral' named entity 'cellular' named entity 'immune cell' named entity 'viral entry' named entity 'Response' named entity 'Immunity' named entity 'MOLECULAR' covid:arg/3f21f365d6a8983fd6cf0406c66d2785d0c3a138 named entity 'ANTIMICROBIAL' named entity 'IFN' named entity 'ACTIVATING' named entity 'RNASE' named entity 'INCLUDING' named entity 'PARTNERS' named entity 'BINDING' named entity 'DSRNA' named entity 'PROTEIN ' named entity 'RNAS' named entity 'PROTEIN X' named entity 'INTERACT' named entity 'ACTIVATION' named entity 'CLEAVES' named entity 'ONE OF' named entity 'REGULATED' named entity 'CYTOSKELETON' named entity 'ANTIMICROBIAL' named entity 'ADDITION' named entity 'INTERFERON ' named entity 'INDEPENDENT OF' named entity 'COMPONENTS' named entity 'GROWING' named entity 'RESPONSE' named entity 'INT' named entity 'FUNCTION' named entity 'ENDORIBONUCLEASE' named entity 'INDUCIBLE' named entity 'CELLULAR' named entity 'MOL' named entity 'LIGAND' named entity 'INNATE IMMUNE RESPONSE' named entity 'NOVEL' named entity 'INFLAMMASOME' named entity 'PATHWAY' named entity 'DOWNREGULATION' named entity 'TO MAINTAIN' named entity 'CATALYTIC' named entity 'THESE' named entity 'VIRAL ENTRY' named entity 'INVOLVED' named entity 'ACTIN-BINDING PROTEIN' named entity 'BETTER' named entity 'GENERATION' named entity 'PRODUCTION' named entity 'SCI' named entity 'GENE' named entity 'NUCLEOTIDE' named entity 'RNASE' named entity 'DESCRIBE' named entity 'LIKE' named entity 'MECHANISM' named entity 'LEADS' named entity 'MULTIPLE' named entity 'CYTOSKELETON' named entity 'EXPRESSION' named entity 'IL-1' named entity 'UNDERSTAND' named entity 'SYNTHETASE' named entity 'CYTOSKELETAL PROTEINS' named entity '2-5A' named entity 'THE CELL' named entity 'SCAFFOLDING PROTEIN' named entity 'ORDER' named entity 'INTERACTION' named entity 'REGULATOR'

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