About: The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responses

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About: The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responses
Creator	Cho, Hee Lee, Seung-Hoon Oh, Jong-Won Sung, Moon-Hee Lee, Wooseong Ahn, Dae-Gyun Han, Hyun
Source	Elsevier; Medline; PMC
abstract	Abstract Poly-γ-glutamic acid (γ-PGA) is an anionic polypeptide secreted by Bacillus sp. that has been shown to activate immune cells through interactions with toll-like receptor 4 (TLR4). However, its ability to induce the type I interferon (IFN) response has not yet been characterized. Here, we demonstrate that γ-PGA induces type I IFN signaling pathway via the TLR4 signaling pathway. The induction required both myeloid differentiation factor 2 (MD2) and the pattern-recognition receptor CD14, which are two TLR4-associated accessory proteins. The γ-PGA with high molecular weights (2000 and 5000 kDa) was able to activate the subsequent signals through TLR4/MD2 to result in dimerization of IRF-3, a transcription factor required for IFN gene expression, leading to increases in mRNA levels of the type I IFN-response genes, 2′–5′ OAS and ISG56. Moreover, γ-PGA (2000 kDa) displayed an antiviral activity against SARS coronavirus and hepatitis C virus. Our results identify high-molecular weight γ-PGA as a TLR4 ligand and demonstrate that γ-PGA requires both CD14 and MD2 for the activation of type I IFN responses. Our results suggest that the microbial biopolymer γ-PGA may have therapeutic potential against a broad range of viruses sensitive to type I IFNs.
has issue date	2013-12-31(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2013.08.067
bibo:pmid	24016850
has license	els-covid
sha1sum (hex)	3ff20c92bf922c29658e1bd1823ac067e810235f
schema:url	https://doi.org/10.1016/j.biomaterials.2013.08.067
resource representing a document's title	The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responses
has PubMed Central identifier	PMC7112489
has PubMed identifier	24016850
schema:publication	Biomaterials
resource representing a document's body	covid:3ff20c92bf922c29658e1bd1823ac067e810235f#body_text
is schema:about of	named entity 'subsequent' named entity 'signaling pathway' named entity 'antiviral' named entity 'demonstrate' named entity 'SECRETED' named entity 'DIMERIZATION' named entity 'MICROBIAL' named entity 'POTENTIAL' named entity 'SARS CORONAVIRUS' named entity 'ANTIVIRAL ACTIVITY' named entity 'DEPENDENT' named entity 'MAY HAVE' named entity 'RECEPTOR' named entity 'TYPE I INTERFERON' named entity 'TLR4' named entity 'DISPLAYED' named entity 'MRNA' named entity 'INTERACTIONS' named entity 'SUBSEQUENT' named entity 'SIGNALING PATHWAY' named entity 'IDENTIFY' named entity 'SENSITIVE TO' named entity 'BIOPOLYMER' named entity 'TRANSCRIPTION FACTOR' named entity 'ISG56' named entity 'FACTOR' named entity 'VIRUSES' named entity 'INTERFERON ' named entity 'THERAPEUTIC' named entity 'PATTERN' named entity 'LEVELS' named entity 'RESPONSES' named entity 'BACILLUS SP.' named entity 'INCREASES' named entity 'GENES' named entity 'HERE' named entity 'LIGAND' named entity '28G' named entity 'MD2' named entity 'GLUTAMIC ACID' named entity 'INDUCTION' named entity 'TYPE I INTERFERON' named entity 'MOLECULAR WEIGHT' named entity '5000' named entity 'KDA' named entity 'TOLL-LIKE RECEPTOR 4' named entity 'BACILLUS SP.' named entity 'ACTIVATE' named entity 'RECOGNITION' named entity 'ACTIVATION' named entity 'HEPATITIS C VIRUS' named entity 'ITS' named entity 'OAS' named entity 'CHARACTERIZED' named entity 'MYELOID' named entity 'INDUCE' named entity 'REQUIRED' named entity 'ACCESSORY' named entity 'RANGE' named entity 'PROTEINS' named entity 'ANTIVIRAL ACTIVITY' named entity 'TLR4 SIGNALING PATHWAY' named entity 'RESULTS' named entity 'LEADING' named entity 'RESPONSE' named entity 'IFN' named entity 'PGA' named entity 'SECRETED' named entity 'POLY' named entity 'CD14' named entity 'OUR' named entity 'IRF-3' named entity 'GLUTAMIC ACID' named entity 'HIGH' named entity 'MOLECULAR WEIGHTS'

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