About: Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome
Creator	Zumla, Alimuddin Drosten, Christian Azhar, Esam Assiri, Abdullah Kellam, Paul Cotten, Matthew Albarrak, Ali Hussain, Raheela Alsubaie, Sarah Alhakeem, Raafat Memish, Ziad Kheyami, Ali Makhdoom, Hatem Al-Rabeeah, Abdullah Al-Tawfiq, Jaffar Watson, Simon Almutairi, Abdullah Hajomar, Waleed
Source	Medline; PMC
abstract	Background. Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. Respiratory tract samples from cases of MERS-CoV infection confirmed by polymerase chain reaction (PCR) were investigated to determine the MERS-CoV load and fraction of the MERS-CoV genome. These values were analyzed to determine associations with clinical sample type. Results. Samples from 112 individuals in which MERS-CoV was detected by PCR were analyzed, of which 13 were sputum samples, 64 were nasopharyngeal swab specimens, 30 were tracheal aspirates, and 3 were bronchoalveolar lavage specimens; 2 samples were of unknown origin. Tracheal aspirates yielded significantly higher MERS-CoV loads, compared with nasopharyngeal swab specimens (P = .005) and sputum specimens (P = .0001). Tracheal aspirates had viral loads similar to those in bronchoalveolar lavage samples (P = .3079). Bronchoalveolar lavage samples and tracheal aspirates had significantly higher genome fraction than nasopharyngeal swab specimens (P = .0095 and P = .0002, respectively) and sputum samples (P = .0009 and P = .0001, respectively). The genome yield from tracheal aspirates and bronchoalveolar lavage samples were similar (P = .1174). Conclusions. Lower respiratory tract samples yield significantly higher MERS-CoV loads and genome fractions than upper respiratory tract samples.
has issue date	2014-11-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiu292
bibo:pmid	24837403
has license	no-cc
sha1sum (hex)	4103e78cbe55b13805347fef2d0a1579d527e496
schema:url	https://doi.org/10.1093/infdis/jiu292
resource representing a document's title	Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome
has PubMed Central identifier	PMC7107391
has PubMed identifier	24837403
schema:publication	J Infect Dis
resource representing a document's body	covid:4103e78cbe55b13805347fef2d0a1579d527e496#body_text
is schema:about of	named entity 'samples' named entity 'Aramco' named entity 'RIYADH' named entity 'VIRAL LOAD' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'VIRAL' named entity 'SAUDI' named entity 'EVOLUTION' named entity 'CLINICAL' named entity 'CRITICAL' named entity 'VIRAL INFECTIONS' named entity 'DIAGNOSIS' named entity 'SEQUENCE DATA' named entity '112' named entity 'TRANSMISSION' named entity 'HEALTH' named entity 'INFECTIOUS DISEASES' named entity 'ANALYSIS' named entity 'SPECIAL' named entity 'MEDICAL SERVICES' named entity 'LABORATORY' named entity 'ORGANIZATION' named entity 'REGIONAL' named entity 'INFECTED' named entity 'SAMPLES' named entity 'ANALYZED' named entity 'CONFIRM' named entity 'SPECIFY' named entity 'BACKGROUND' named entity 'RECENTLY' named entity 'NECESSARY' named entity 'PATIENTS' named entity 'NEW' named entity 'KINETICS' named entity 'UNIT' covid:arg/4103e78cbe55b13805347fef2d0a1579d527e496 named entity 'transmission' named entity 'patients' named entity 'clinical samples' named entity 'MERS-CoV' named entity 'Saudi Aramco Medical Services Organization' named entity 'palate' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'clinical samples' named entity 'MERS-CoV' named entity 'sputum' named entity 'SARS' named entity 'infection' named entity 'RNA' named entity 'sputum' named entity 'intensive care unit' named entity 'nucleic acid' named entity 'infection' named entity 'MERS-CoV' named entity 'infection control' named entity 'respiratory tract' named entity 'data set' named entity 'MERS-CoV' named entity 'SARS-CoV' named entity 'deep sequencing' named entity 'infection' named entity 'nasopharyngeal swab' named entity 'genome'

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