About: Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

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About: Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a
Creator	Duan, Yueqiang Gu, Hongjing Lai, Chengcai Wang, Keyu Wang, Xiliang Yang, Penghui Zhao, Zhongpeng Chen, Runsheng Wang, Cheng Zhang, Cheng, Sijie Lili, Lingna, Liu, Lihui Liu, Qinghua Liu, Ziyang Luo, Jianjun Song, Jianxun Xia, Min
Source	BioRxiv; MedRxiv
abstract	Accumulating evidence has shown that long noncoding RNAs (lncRNAs) are involved in several biological processes, including immune responses. However, the role of lncRNAs in antiviral innate immune responses remains largely unexplored. Here, we identify an uncharacterized human lncRNA from influenza A virus (IAV) patients, antivirus and activate neutrophil (AVAN), that is significantly up-regulated upon virus infection. Mechanistically, nuclear lncRNA-AVAN positively regulates the transcription of forkhead box O3A (FOXO3a) by associating with its promoter and inducing chromatin remodeling to promote neutrophil chemotaxis. Furthermore, we also found that cytoplasmic lncRNA-AVAN directly binds tripartite motif containing 25 (TRIM25) and enhances the association of TRIM25 and Retinoic acid inducible gene-1 proteins (RIG-I) and the ubiquitylation of RIG-I, thereby promoting TRIM25- and RIG-I-mediated antiviral innate immune signaling. More importantly, we enforced the expression of AVAN in transgenic mice and found that it significantly alleviated IAV virulence and virus production. Collectively, these findings highlight the potential clinical implications of lncRNA-AVAN as a key positive regulator of the antiviral innate immune response and a promising target for developing broad antiviral therapeutics.
has issue date	2019-04-30(xsd:dateTime)
bibo:doi	10.1101/623132
has license	medrxiv
sha1sum (hex)	42311b11c5256d17559b1bbda5acc951593e6406
schema:url	https://doi.org/10.1101/623132
resource representing a document's title	Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a
schema:publication	bioRxiv
resource representing a document's body	covid:42311b11c5256d17559b1bbda5acc951593e6406#body_text
is schema:about of	named entity 'promising' named entity 'innate immune responses' named entity 'lncRNAs' named entity 'potential' named entity 'potential' named entity 'antiviral' named entity 'RIG-I' named entity 'immunity' named entity 'innate immune' named entity 'positive' named entity 'forkhead box' named entity 'noncoding' named entity 'However' named entity 'proliferation' named entity 'AVAN' named entity 'neutrophil' named entity 'cis' named entity 'A549' named entity 'TRIM25' named entity 'lncRNAs' named entity 'cytokine' named entity 'chemotaxis' named entity 'virus infection' named entity 'lncRNAs' named entity 'lncRNA' named entity 'antiviral' named entity 'biological processes' named entity 'RIG-I' named entity 'Long noncoding RNA' named entity 'TRIM25' named entity 'proliferation' named entity 'RNAs' named entity 'endogenous' named entity 'CXCL2' named entity 'Kodak' named entity 'OASL' named entity 'overexpressing' named entity 'IAV' named entity 'IAV' named entity 'AAV2' named entity 'lncRNA' named entity 'type I IFN' named entity 'IAV' named entity 'qRT-PCR' named entity 'inflammatory diseases' named entity 'reverse transcription' named entity 'neutrophil' named entity 'A549' named entity 'IAV' named entity 'TRIM25' named entity 'IAV' named entity 'overexpressing' named entity 'Primer pairs' named entity 'RIG-I' named entity 'infection' named entity 'down-regulated' named entity 'lncRNAs' named entity 'neutrophil' named entity 'cytoplasm' named entity 'p<0.05' named entity 'Gene ontology' named entity 'human genome' named entity 'infection' named entity 'exogenous' named entity 'antiviral' named entity 'nucleus'

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