About: Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study

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About: Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study
Creator	Cianflone, M Lanzafame, A Mattina, R Rondini, G Santini, L Cocuzza, C
Source	Elsevier; Medline; PMC
abstract	Abstract A total of 123 community paediatricians and 23 microbiology laboratories studied the clinical and bacteriological efficacy of treatment of group A streptococcal pharyngitis in Italy. Of 1065 patients, from whom Streptococcus pyogenes was isolated, 723 returned to follow up and of these 138 (19%) still had a positive throat culture. The erythromycin resistance (ER) rate was 23.7% with resistance phenotype distribution of: 31.7% constitutive (CR), 26.6% inducible (IR) and 41.7% efflux pump (M) resistance phenotype. All strains were susceptible to the β-lactam agents tested. CR strains were highly resistant to all 14, 15 and 16 membered macrolides with the exception of rokitamycin which showed activity against 37.8% of isolates. All phenotype M and some IR isolates were susceptible to clindamycin, rokitamycin, josamycin and spiramycin; clarithromycin was active against a small percentage of strains belonging to the IR and M phenotype. Bacterial eradication was found in 85.5, 78.7 and 75.8% of the penicillin, macrolide and cephalosporin treated groups. Genotyping of strains showed that 8.7% of the 19% of cases classified as ‘failed bacterial eradication’ were due to recolonization with a different isolate, observed exclusively among β-lactams treated patients. Clinical cure was achieved in a high percentage of cases, irrespective of the antibiotic prescribed, with the best clinical efficacy being found following therapy with amoxycillin and clarithromycin (90.9%).
has issue date	2001-07-31(xsd:dateTime)
bibo:doi	10.1016/s0924-8579(01)00342-9
bibo:pmid	11463521
has license	els-covid
sha1sum (hex)	42b94d733f1b278e62fdcfa722740da9e092da56
schema:url	https://doi.org/10.1016/s0924-8579%2801%2900342-9
resource representing a document's title	Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study
has PubMed Central identifier	PMC7135440
has PubMed identifier	11463521
schema:publication	International Journal of Antimicrobial Agents
resource representing a document's body	covid:42b94d733f1b278e62fdcfa722740da9e092da56#body_text
is schema:about of	named entity 'VARIOUS' named entity 'cases' named entity 'bacterial' named entity 'All' named entity 'isolate' named entity 'streptococcal pharyngitis' named entity 'active' named entity 'patients' named entity 'macrolide' named entity 'clarithromycin' named entity 'ITALY' named entity 'STREPTOCOCCAL PHARYNGITIS' named entity 'TREATMENT' named entity 'STREPTOCOCCUS PYOGENES' named entity 'POSITIVE' named entity 'BEST' named entity 'THROAT CULTURE' named entity 'ERYTHROMYCIN' named entity 'GENOTYPING' named entity 'ERADICATION' named entity 'SUSCEPTIBLE' named entity '31.7' named entity 'BEING' named entity 'BACTERIOLOGICAL' named entity 'CLINICAL' named entity '8.7' named entity 'DUE TO' named entity 'SMALL' named entity 'FOLLOWING' named entity 'GROUP A STREPTOCOCCAL PHARYNGITIS' named entity 'CEPHALOSPORIN' named entity 'ACTIVE' named entity 'USED' named entity 'RESISTANT TO' named entity 'SPIRAMYCIN' named entity 'LABORATORIES' named entity 'INDUCIBLE' named entity 'OBSERVED' named entity 'PATIENTS' named entity 'LACTAMS' named entity 'PHENOTYPE' named entity 'BACTERIAL' named entity 'LACTAM' named entity 'CLINDAMYCIN' named entity 'CLINICAL EFFICACY' named entity 'EPIDEMIOLOGICAL STUDY' named entity 'TREATMENT' named entity 'PENICILLIN' named entity 'PERCENTAGE' named entity 'EFFLUX PUMP' named entity '723' named entity 'HIGHLY' named entity 'EXCEPTION' named entity 'MICROBIOLOGY' named entity 'ACTIVITY' named entity 'STRAINS' named entity 'AMOXYCILLIN' named entity 'MACROLIDES' named entity 'CASES' named entity 'PRESCRIBED' named entity 'HIGH PERCENTAGE' named entity 'GROUPS' named entity 'BACTERIOLOGICAL' named entity 'CLINICAL CURE' named entity 'RETURNED' named entity 'CLARITHROMYCIN' named entity 'MACROLIDE' named entity 'THESE' named entity 'ANTIBIOTIC' named entity 'JOSAMYCIN' named entity 'CLINICAL EFFICACY' named entity 'TESTED' named entity 'COMMUNITY' named entity 'ISOLATE' named entity 'FOLLOW UP' named entity 'DIFFERENT'

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