About: Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study

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About: Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study
Creator	Shi, Yi Wang, Li Tan, Yan Su, Xin Zhao, Jiangnan
Source	PMC
abstract	BACKGROUND: Sphingosine-1-phosphate (S1P) is a signaling phospholipid involved in pathophysiologic progression of acute respiratory distress syndrome (ARDS) through its roles in endothelial barrier function and immune modulation. We hypothesized that decreased serum S1P level is associated with the clinical outcomes of ARDS and polymorphisms in the S1P gene are associated with serum S1P levels. METHODS: This multicenter prospective study includes ARDS patients and healthy blood donors as controls. Serum S1P levels were quantified using enzyme-linked immunosorbent assays. Eight tag single nucleotide polymorphisms (SNPs) in the S1P gene were detected, and their associations with S1P levels were evaluated. RESULTS: A total of 121 ARDS patients and 100 healthy individuals were enrolled. Serum S1P levels were lower in ARDS patients than in controls (P < 0.001). Decreased S1P levels correlated with more organ dysfunction and higher Acute Physiology and Chronic Health Evaluation II scores. Changes in S1P levels in ARDS patients were associated with the clinical outcomes. The recessive model for SNP rs3743631 suggests that GG homozygote is associate with a higher risk for ARDS. The dominant model for SNP rs907045 suggests that AA or TA genotype might increase the risk for ARDS. In ARDS patients, the rs3743631 GG genotype showed lower S1P levels than those harboring AG and AA genotypes. The serum S1P levels of rs907045 AA or TA genotype patients were lower than those of TT genotype. CONCLUSIONS: Serum S1P levels are dramatically decreased in ARDS patients. Reduced S1P levels are associated with worse clinical outcomes. There is a significant association between S1P rs3743631, rs907045 polymorphisms and susceptibility of ARDS.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.1186/s12967-020-02322-y
bibo:pmid	32252779
has license	cc-by
sha1sum (hex)	43070120d03543d305a0d1e8bbece4aeb49ca409
schema:url	https://doi.org/10.1186/s12967-020-02322-y
resource representing a document's title	Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study
has PubMed Central identifier	PMC7137241
has PubMed identifier	32252779
schema:publication	J Transl Med
resource representing a document's body	covid:43070120d03543d305a0d1e8bbece4aeb49ca409#body_text
is schema:about of	named entity 'acute respiratory distress syndrome' named entity 'levels' named entity 'gene' named entity 'phospholipid' named entity 'ARDS' named entity 'clinical outcomes' named entity 'S1P' named entity 'endothelial' named entity 'acute respiratory distress syndrome' named entity 'Serum' named entity 'blood samples' named entity 'sphingosine-1-phosphate' named entity 'ARDS' named entity 'ARDS' named entity 'S1P' named entity 'Acute respiratory distress syndrome' named entity 'albumin' named entity 'endothelial' named entity 'receiver operating characteristic' named entity 'Confidence interval' named entity 'odds ratio' named entity 'S1P' named entity 'S1P' named entity 'Serum' named entity 'Salt Lake City' named entity 'agonist' named entity 'ARDS' named entity 'Nanjing' named entity 'endothelial cell' named entity 'ROC' named entity 'genetic differences' named entity 'vital signs' named entity 'sample size' named entity 'S1P' named entity 'lung edema' named entity 'polymorphisms' named entity 'Recessive' named entity 'innate immune cell' named entity 'S1P' named entity 'S1P' named entity 'gene' named entity 'gene' named entity 'nmol/L' named entity 'genotypes' named entity 'Single nucleotide polymorphisms' named entity 'SNPs' named entity 'S1P' named entity 'S1P' named entity 'S1P' named entity 'S1P' named entity 'animal models' named entity 'SNPs' named entity 'Untranslated region' named entity 'S1P' named entity 'S1P' named entity 'immunosuppression' named entity 'S1P' named entity 'RBCs' named entity 'linear correlation' named entity 'S1P' named entity 'S1P' named entity 'risk factors' named entity 'multiple organ dysfunction' named entity 'ARDS' named entity 'serum levels' named entity 'allele frequency' named entity '5′ untranslated region' named entity 'ARDS' named entity 'S1P' named entity 'endothelial' named entity 'S1P' named entity 'S1P' named entity 'Berlin' named entity 'nmol/L' named entity 'endothelial' named entity 'ARDS' named entity 'S1P'

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