About: Antiviral activity of silymarin against chikungunya virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antiviral activity of silymarin against chikungunya virus
Creator	Higgs, Stephen Abu Bakar, Sazaly Hassandarvish, Pouya Lani, Rafidah Merits, Andres Moghaddam, Ehsan Rausalu, Kai Vanlandingham, Dana Zandi, Keivan Chu, Hann Jang, Justin Chiam, Chun
source	Medline; PMC
abstract	The mosquito-borne chikungunya virus (CHIKV) causes chikungunya fever, with clinical presentations such as severe back and small joint pain, and debilitating arthritis associated with crippling pains that persist for weeks and even years. Although there are several studies to evaluate the efficacy of drugs against CHIKV, the treatment for chikungunya fever is mainly symptom-based and no effective licensed vaccine or antiviral are available. Here, we investigated the antiviral activity of three types of flavonoids against CHIKV in vitro replication. Three compounds: silymarin, quercetin and kaempferol were evaluated for their in vitro antiviral activities against CHIKV using a CHIKV replicon cell line and clinical isolate of CHIKV of Central/East African genotype. A cytopathic effect inhibition assay was used to determine their activities on CHIKV viral replication and quantitative reverse transcription PCR was used to calculate virus yield. Antiviral activity of effective compound was further investigated by evaluation of CHIKV protein expression using western blotting for CHIKV nsP1, nsP3, and E2E1 proteins. Briefly, silymarin exhibited significant antiviral activity against CHIKV, reducing both CHIKV replication efficiency and down-regulating production of viral proteins involved in replication. This study may have important consequence for broaden the chance of getting the effective antiviral for CHIKV infection.
has issue date	2015-06-16(xsd:dateTime)
bibo:doi	10.1038/srep11421
bibo:pmid	26078201
has license	cc-by
sha1sum (hex)	43c284998733a1d7cc474d14c378f08e4b509c63
schema:url	https://doi.org/10.1038/srep11421
resource representing a document's title	Antiviral activity of silymarin against chikungunya virus
has PubMed Central identifier	PMC4468427
has PubMed identifier	26078201
schema:publication	Sci Rep
resource representing a document's body	covid:43c284998733a1d7cc474d14c378f08e4b509c63#body_text
is schema:about of	named entity 'efficiency' named entity 'antiviral' named entity 'genotype' named entity 'Three' named entity 'quercetin' covid:arg/43c284998733a1d7cc474d14c378f08e4b509c63 named entity 'CHIKUNGUNYA VIRUS' named entity 'KAEMPFEROL' named entity 'GENOTYPE' named entity 'INVESTIGATED' named entity 'SYMPTOM' named entity 'REDUCING' named entity 'WEEKS' named entity 'EVALUATE' named entity 'LICENSED VACCINE' named entity 'STUDIES' named entity 'CENTRAL' named entity 'VIRAL REPLICATION' named entity 'USED' named entity 'ANTIVIRAL' named entity 'PRESENTATIONS' named entity 'SILYMARIN' named entity 'EFFECTIVE' named entity 'TREATMENT' named entity 'QUANTITATIVE REVERSE TRANSCRIPTION PCR' named entity 'VIRUS' named entity 'YEARS' named entity 'CHIKUNGUNYA FEVER' named entity 'AVAILABLE' named entity 'CHIKUNGUNYA VIRUS' named entity 'ASSAY' named entity 'CAUSES' named entity 'CELL LINE' named entity 'REPLICATION' named entity 'CLINICAL' named entity 'BORNE' named entity 'MOSQUITO' named entity 'IMPORTANT' named entity 'INHIBITION' named entity 'PRODUCTION' named entity 'DRUGS' named entity 'CRIPPLING' named entity 'CHANCE' named entity 'TYPES' named entity 'ARTHRITIS' named entity 'THEIR' named entity 'TO CALCULATE' named entity 'COMPOUND' named entity 'IN VITRO' named entity 'CLINICAL ISOLATE' named entity 'ANTIVIRAL ACTIVITY' named entity 'NSP1' named entity 'PROTEINS' named entity 'ASSOCIATED WITH' named entity 'ACTIVITIES' named entity 'VIRAL PROTEINS' named entity 'ANTIVIRAL ACTIVITY' named entity 'SILYMARIN' named entity 'CONSEQUENCE' named entity 'AFRICAN' named entity 'EFFICACY' named entity 'BASED' named entity 'DETERMINE' named entity 'EFFICIENCY' named entity 'CYTOPATHIC EFFECT' named entity 'WESTERN BLOTTING' named entity 'PAINS' named entity 'HERE' named entity 'EVALUATION' named entity 'REPLICON'

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