About: Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case

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About: Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case–control study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case–control study
Creator	Bagheri-Hanson, Azadeh Naehrlich, Lutz Nedwed, Sebastian Rueckes-Nilges, Claudia
Source	PMC
abstract	BACKGROUND: Nasal potential difference (NPD) and intestinal current measurement (ICM) are functional CFTR tests that are used as adjunctive diagnostic tools for cystic fibrosis (CF). Smoking has a systemic negative impact on CFTR function. A diagnostic comparison between NPD and ICM and the impact of smoking on both CFTR tests has not been done. METHODS: The sweat chloride test, NPD, and ICM were performed in 18 patients with CF (sweat chloride >60 mmol/l), including 6 pancreatic sufficient (PS) patients, and 13 healthy controls, including 8 smokers. The NPD CFTR response to Cl-free and isoproterenol perfusion (Δ0Cl(-) + Iso) was compared to the ICM CFTR response to forskolin/IBMX, carbachol, and histamine (ΔI(sc, forskolin/IBMX+ carbachol+histamine)). RESULTS: The mean NPD CFTR response and ICM CFTR response between patients with CF and healthy controls was significantly different (p <0.001), but not between patients with CF who were PS and those who were pancreatic insufficient (PI). Smokers have a decreased CFTR response measured by NPD (p = 0.049). For ICM there is a trend towards decreased CFTR response (NS). Three healthy control smokers had NPD responses within the CF-range. In contrast to NPD, there was no overlap of the ICM response between patients with CF and controls. CONCLUSIONS: ICM is superior to NPD in distinguishing between patients with CF who have a sweat chloride > 60 mmol/l and healthy controls, including smokers. Neither NPD nor ICM differentiated between patients with CF who were PS from those who were PI. Smoking has a negative impact on CFTR function in healthy controls measured by NPD and challenges the diagnostic interpretation of NPD, but not ICM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2466-14-156) contains supplementary material, which is available to authorized users.
has issue date	2014-10-04(xsd:dateTime)
bibo:doi	10.1186/1471-2466-14-156
bibo:pmid	25280757
has license	cc-by
sha1sum (hex)	43c296a219a62ac9f9a632490034b6fdfc7b871e
schema:url	https://doi.org/10.1186/1471-2466-14-156
resource representing a document's title	Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case–control study
has PubMed Central identifier	PMC4199064
has PubMed identifier	25280757
schema:publication	BMC Pulm Med
resource representing a document's body	covid:43c296a219a62ac9f9a632490034b6fdfc7b871e#body_text
is schema:about of	named entity 'smokers' named entity 'NPD' named entity 'mmol' named entity 'NPD' named entity 'sweat' named entity 'ICM' named entity 'Smoking' named entity 'patients' named entity 'cystic fibrosis' named entity 'diagnosis' named entity 'POTENTIAL' named entity 'CURRENT' named entity 'PATIENTS' named entity 'CURRENT' named entity 'RANGE' named entity 'CHLORIDE' named entity 'IMPACT' named entity 'INTERPRETATION' named entity 'METHODS' named entity 'TESTS' named entity 'ICM' named entity 'DIFFERENTIATED' named entity 'CL-' named entity 'PERFUSION' named entity 'SMOKING' named entity 'MEAN' named entity 'DECREASED' named entity 'CFTR' named entity 'IS A' named entity 'RESPONSE' named entity 'FORSKOLIN' named entity 'COMPARISON' named entity 'USED' named entity 'POTENTIAL' named entity 'SYSTEMIC' named entity 'CONTRAST' named entity 'OVERLAP' named entity 'MMOL' named entity 'SMOKERS' named entity 'PERFORMED' named entity 'NEGATIVE' named entity 'SUPERIOR' named entity 'FREE' named entity 'MEASUREMENT' named entity 'CARBACHOL' named entity 'HAVE' named entity 'BUT' named entity 'RESPONSE TO' covid:arg/43c296a219a62ac9f9a632490034b6fdfc7b871e named entity 'MEASURED' named entity 'INSUFFICIENT' named entity 'NEITHER' named entity 'INTESTINAL' named entity 'CYSTIC FIBROSIS' named entity 'MEASUREMENT' named entity 'CASE-CONTROL STUDY' named entity 'TREND' named entity 'ISO' named entity 'RESPONSES' named entity 'FOR DIAGNOSIS' named entity 'NASAL' named entity 'DIFFERENCE' named entity 'DISTINGUISHING' named entity 'TOOLS' named entity 'ISOPROTERENOL' named entity 'DIFFERENCE' named entity 'BACKGROUND' named entity 'HEALTHY' named entity 'FUNCTIONAL' named entity 'SUFFICIENT' named entity 'RESPONSE TO FORSKOLIN' named entity 'SWEAT CHLORIDE TEST' named entity 'CYSTIC FIBROSIS' named entity 'NASAL' named entity 'FUNCTION' named entity 'ADJUNCTIVE' named entity 'INCLUDING' named entity 'DIAGNOSTIC'

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