About: Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: Identification of a candidate etiologic agent

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About: Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: Identification of a candidate etiologic agent Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: Identification of a candidate etiologic agent
Creator	Chiu, Charles Clubb, Susan Ganem, Don Farnoushi, Yigal Fischer, Kael Gancz, Ady Greninger, Alexander Lublin, Avishai Mechani, Sara Skewes-Cox, Peter Sorber, Katherine Derisi, Joseph Karlene, Scott Kistler, Amy Wen, Christopher
Source	Medline; PMC
abstract	BACKGROUND: Proventricular dilatation disease (PDD) is a fatal disorder threatening domesticated and wild psittacine birds worldwide. It is characterized by lymphoplasmacytic infiltration of the ganglia of the central and peripheral nervous system, leading to central nervous system disorders as well as disordered enteric motility and associated wasting. For almost 40 years, a viral etiology for PDD has been suspected, but to date no candidate etiologic agent has been reproducibly linked to the disease. RESULTS: Analysis of 2 PDD case-control series collected independently on different continents using a pan-viral microarray revealed a bornavirus hybridization signature in 62.5% of the PDD cases (5/8) and none of the controls (0/8). Ultra high throughput sequencing was utilized to recover the complete viral genome sequence from one of the virus-positive PDD cases. This revealed a bornavirus-like genome organization for this agent with a high degree of sequence divergence from all prior bornavirus isolates. We propose the name avian bornavirus (ABV) for this agent. Further specific ABV PCR analysis of an additional set of independently collected PDD cases and controls yielded a significant difference in ABV detection rate among PDD cases (71%, n = 7) compared to controls (0%, n = 14) (P = 0.01; Fisher's Exact Test). Partial sequence analysis of a total of 16 ABV isolates we have now recovered from these and an additional set of cases reveals at least 5 distinct ABV genetic subgroups. CONCLUSION: These studies clearly demonstrate the existence of an avian reservoir of remarkably diverse bornaviruses and provide a compelling candidate in the search for an etiologic agent of PDD.
has issue date	2008-07-31(xsd:dateTime)
bibo:doi	10.1186/1743-422x-5-88
bibo:pmid	18671869
has license	cc-by
sha1sum (hex)	43f0ed0ead4058d6f92c7390c15d0d9fe66af448
schema:url	https://doi.org/10.1186/1743-422x-5-88
resource representing a document's title	Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: Identification of a candidate etiologic agent
has PubMed Central identifier	PMC2546392
has PubMed identifier	18671869
schema:publication	Virol J
resource representing a document's body	covid:43f0ed0ead4058d6f92c7390c15d0d9fe66af448#body_text
is schema:about of	named entity 'wild' named entity 'disorder' named entity 'avian' named entity 'DILATATION' named entity 'IS A' named entity 'BUT' named entity 'GANGLIA' named entity 'WORLDWIDE' named entity 'VIRAL' named entity 'DISORDERED' named entity 'SUSPECTED' named entity 'LEADING' named entity 'WASTING' named entity 'DILATATION' named entity 'ALMOST' named entity 'PDD' named entity 'INFILTRATION' named entity 'ASSOCIATED' named entity 'ETIOLOGIC AGENT' named entity 'BIRDS' named entity 'AVIAN' named entity 'DISEASE' named entity 'CANDIDATE' named entity 'BACKGROUND' named entity 'ETIOLOGY' named entity 'RECOVERY' named entity 'DATE' named entity 'DISORDER' named entity 'WILD' named entity 'ETIOLOGIC AGENT' named entity 'IDENTIFICATION' named entity 'JOURNAL ' named entity 'VIROLOGY' named entity 'BORNAVIRUSES' named entity 'CENTRAL NERVOUS SYSTEM DISORDERS' named entity 'CHARACTERIZED' named entity 'CENTRAL' named entity 'YEARS' named entity 'PERIPHERAL NERVOUS SYSTEM' named entity 'CANDIDATE' named entity 'CASES' named entity 'ENTERIC' named entity 'DISEASE' named entity 'FATAL' named entity 'MOTILITY' named entity 'LYMPHOPLASMACYTIC' covid:arg/43f0ed0ead4058d6f92c7390c15d0d9fe66af448 named entity 'fatal' named entity 'For' named entity 'Background' named entity 'PDD' named entity 'ABV' named entity 'nucleotides' named entity 'transcription' named entity 'taxonomic' named entity 'phosphorylated' named entity 'RNA' named entity 'RNA' named entity 'myenteric' named entity 'sequence divergence' named entity 'PDD' named entity 'Solexa' named entity 'ABV' named entity 'RNA' named entity 'Bornaviridae' named entity 'PDD' named entity 'phylogenetic analyses'

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