About: Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation
Creator	Hieda, Y Koshino, A Mima, J Oka, K Uchida, H
Source	PMC
abstract	Cleft palate results from a mixture of genetic and environmental factors and occurs when the bilateral palatal shelves fail to fuse. The objective of this study was to search for new genes involved in mouse palate formation. Gene expression of murine embryonic palatal tissue was analyzed at various developmental stages before, during, and after palate fusion using GeneChip® microarrays. Ceacam1 was one of the highly up-regulated genes during palate formation, and this was confirmed by quantitative real-time PCR. Immunohistochemical staining showed that CEACAM1 was present in prefusion palatal epithelium and was degraded during fusion. To investigate the developmental role of CEACAM1, function-blocking antibody was added to embryonic mouse palate in organ culture. Palatal fusion was inhibited by this function-blocking antibody. To investigate the subsequent developmental role of CEACAM1, we characterized Ceacam1-deficient (Ceacam1 (−/−)) mice. Epithelial cells persisted abnormally at the midline of the embryonic palate even on day E16.0, and palatal fusion was delayed in Ceacam1 (−/−) mice. TGFβ3 expression, apoptosis, and cell proliferation in palatal epithelium were not affected in the palate of Ceacam1(−/−)mice. However, CEACAM1 expression was retained in the remaining MEE of TGFβ-deficient mice. These results suggest that CEACAM1 has roles in the initiation of palatal fusion via epithelial cell adhesion.
has issue date	2013-04-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0061653
bibo:pmid	23613893
has license	cc-by
sha1sum (hex)	44f9f629bf4db860b1cbb1cce7f925d0f7d29b30
schema:url	https://doi.org/10.1371/journal.pone.0061653
resource representing a document's title	Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation
has PubMed Central identifier	PMC3629100
has PubMed identifier	23613893
schema:publication	PLoS One
resource representing a document's body	covid:44f9f629bf4db860b1cbb1cce7f925d0f7d29b30#body_text
is schema:about of	named entity 'investigate' named entity 'apoptosis' named entity 'genes' named entity 'antibody' named entity 'quantitative real-time PCR' named entity 'TGFb3' named entity 'EPITHELIAL' named entity 'ADHESION MOLECULE' named entity 'AFFECTED' named entity 'PALATE' named entity 'PALATAL' named entity 'USING' named entity 'CEACAM1' named entity 'REGULATION' named entity 'BILATERAL' named entity 'FUSION' named entity 'SEARCH' named entity 'OBJECTIVE' named entity 'DAY' named entity 'E16' named entity 'TO INVESTIGATE' named entity 'ANALYZED' named entity 'DELAYED' named entity 'EMBRYONIC PALATE' named entity 'DEVELOPMENTAL STAGES' named entity 'SUGGEST' named entity 'DEGRADED' named entity 'ORGAN CULTURE' named entity 'THESE' named entity 'FAIL' named entity 'IMPORTANT' named entity 'PRESENT' named entity 'RESULTS' named entity 'CELL ADHESION' named entity 'EXPRESSION' named entity 'GENE EXPRESSION' named entity 'INVOLVED' named entity 'HIGHLY' named entity 'DEVELOPMENTAL' named entity 'ENVIRONMENTAL FACTORS' named entity 'MIDLINE' named entity 'BLOCKING ANTIBODY' named entity 'GENES' named entity 'CHARACTERIZED' named entity 'EMBRYONIC' named entity 'RETAINED' named entity 'TISSUE' named entity 'APOPTOSIS' named entity 'FUSE' named entity 'IMMUNOHISTOCHEMICAL STAINING' named entity 'MOUSE' named entity 'MIXTURE' named entity 'FORMATION' named entity 'UP-REGULATED' named entity 'ROLE' named entity 'VARIOUS' named entity 'CONFIRMED BY' named entity 'TGFB' named entity 'PALATAL SHELVES' named entity 'MEE' named entity 'INHIBITED' named entity 'FUNCTION' named entity 'MICE' named entity 'EPITHELIAL CELLS' named entity 'SUBSEQUENT' named entity 'MICROARRAYS' named entity 'PALATE' named entity 'EPITHELIUM' named entity 'EPITHELIAL CELL' named entity 'NEW' named entity 'ROLES' named entity 'GENETIC' named entity 'CLEFT PALATE' named entity 'TGFB3' named entity 'QUANTITATIVE REAL-TIME PCR' named entity 'CEACAM1' named entity 'ADDED'

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