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ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
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research paper
schema:ScholarlyArticle
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Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
Creator
Tan, Yee-Joo
Wang, Yue
Chou, Chih-Fong
Hong, Wanjin
Khan, Sehaam
Fu, Jianlin
Tan, Timothy
Chay, Boon
Chou, C.-F
Fielding,
Foo, Shuo
Lim, Gee
Loh, Khoon
Shen, Burtram
Source
Elsevier; Medline; PMC
abstract
Abstract Angiotensin-converting enzyme 2 (ACE2), a newly identified member in the renin–angiotensin system (RAS), acts as a negative regulator of ACE. It is mainly expressed in cardiac blood vessels and the tubular epithelia of kidneys and abnormal expression has been implicated in diabetes, hypertension and heart failure. The mechanism and physiological function of this zinc metallopeptidase in mammals are not yet fully understood. Non-mammalian vertebrate models offer attractive and simple alternatives that could facilitate the exploration of ACE2 function. In this paper we report the in silico analysis of Ace2 genes from the Gallus (chicken), Xenopus (frog), Fugu and Tetraodon (pufferfish) genome assembly databases, and from the Danio (zebrafish) cDNA library. Exon ambiguities of Danio and Xenopus Ace2s were resolved by RT-PCR and 3′RACE. Analyses of the exon–intron structures, alignment, phylogeny and hydrophilicity plots, together with the conserved synteny among these vertebrates, support the orthologous relationship between mammalian and non-mammalian ACE2s. The putative promoters of Ace2 from human, Tetraodon and Xenopus tropicalis drove the expression of enhanced green fluorescent protein (EGFP) specifically in the heart tissue of transgenic Xenopus thus making it a suitable model for future functional genomic studies. Additionally, the search for conserved cis-elements resulted in the discovery of WGATAR motifs in all the putative Ace2 promoters from 7 different animals, suggesting a possible role of GATA family transcriptional factors in regulating the expression of Ace2.
has issue date
2006-08-01
(
xsd:dateTime
)
bibo:doi
10.1016/j.gene.2006.03.010
bibo:pmid
16781089
has license
els-covid
sha1sum (hex)
4518e94c8d782b510f4cd492c26736cd41bb1d75
schema:url
https://doi.org/10.1016/j.gene.2006.03.010
resource representing a document's title
ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
has PubMed Central identifier
PMC7125734
has PubMed identifier
16781089
schema:publication
Gene
resource representing a document's body
covid:4518e94c8d782b510f4cd492c26736cd41bb1d75#body_text
is
schema:about
of
named entity 'transcriptional factors'
named entity 'transgenic'
named entity 'genome'
named entity 'cardiac'
named entity 'expression'
named entity 'function'
named entity 'making'
named entity 'green fluorescent protein'
named entity 'Xenopus'
named entity 'abnormal'
named entity 'pufferfish'
named entity 'Gallus'
named entity 'chicken'
named entity 'plots'
named entity 'PROMOTERS'
named entity 'ACE2'
named entity 'CONSERVED SYNTENY'
named entity 'MECHANISM'
named entity 'MODELS'
named entity 'TETRAODON'
named entity 'HYDROPHILICITY'
named entity 'MEMBER'
named entity 'DIFFERENT'
named entity 'HEART TISSUE'
named entity 'BLOOD VESSELS'
named entity 'UNDERSTOOD'
named entity 'FULLY'
named entity 'STRUCTURES'
named entity 'CONSERVED'
named entity 'KIDNEYS'
named entity 'MOTIFS'
named entity 'GENOME ASSEMBLY'
named entity 'HYPERTENSION'
named entity 'RESOLVED'
named entity 'ACTS'
named entity 'ZINC'
covid:arg/4518e94c8d782b510f4cd492c26736cd41bb1d75
named entity 'STUDIES'
named entity 'CARDIAC'
named entity 'THESE'
named entity 'SEARCH'
named entity 'XENOPUS'
named entity 'EXPLORATION'
named entity 'ABNORMAL'
named entity 'DIABETES'
named entity 'GALLUS'
named entity 'IN SILICO ANALYSIS'
named entity 'METALLOPEPTIDASE'
named entity 'FUTURE'
named entity 'MODEL'
named entity 'DANIO'
named entity 'SUITABLE'
named entity 'PAPER'
named entity 'TRANSGENIC'
named entity 'ACE'
named entity 'ENHANCED GREEN FLUORESCENT PROTEIN'
named entity 'ROLE'
named entity 'NEWLY'
named entity 'RELATIONSHIP'
named entity 'TUBULAR'
named entity 'DATABASES'
named entity 'MAMMALS'
named entity 'NON-MAMMALIAN'
named entity 'DISCOVERY'
named entity 'VERTEBRATE'
named entity 'ALIGNMENT'
named entity 'ORTHOLOGOUS'
named entity 'EXPRESSED'
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