About: ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)

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About: ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus) Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
Creator	Tan, Yee-Joo Wang, Yue Chou, Chih-Fong Hong, Wanjin Khan, Sehaam Fu, Jianlin Tan, Timothy Chay, Boon Chou, C.-F Fielding, Foo, Shuo Lim, Gee Loh, Khoon Shen, Burtram
Source	Elsevier; Medline; PMC
abstract	Abstract Angiotensin-converting enzyme 2 (ACE2), a newly identified member in the renin–angiotensin system (RAS), acts as a negative regulator of ACE. It is mainly expressed in cardiac blood vessels and the tubular epithelia of kidneys and abnormal expression has been implicated in diabetes, hypertension and heart failure. The mechanism and physiological function of this zinc metallopeptidase in mammals are not yet fully understood. Non-mammalian vertebrate models offer attractive and simple alternatives that could facilitate the exploration of ACE2 function. In this paper we report the in silico analysis of Ace2 genes from the Gallus (chicken), Xenopus (frog), Fugu and Tetraodon (pufferfish) genome assembly databases, and from the Danio (zebrafish) cDNA library. Exon ambiguities of Danio and Xenopus Ace2s were resolved by RT-PCR and 3′RACE. Analyses of the exon–intron structures, alignment, phylogeny and hydrophilicity plots, together with the conserved synteny among these vertebrates, support the orthologous relationship between mammalian and non-mammalian ACE2s. The putative promoters of Ace2 from human, Tetraodon and Xenopus tropicalis drove the expression of enhanced green fluorescent protein (EGFP) specifically in the heart tissue of transgenic Xenopus thus making it a suitable model for future functional genomic studies. Additionally, the search for conserved cis-elements resulted in the discovery of WGATAR motifs in all the putative Ace2 promoters from 7 different animals, suggesting a possible role of GATA family transcriptional factors in regulating the expression of Ace2.
has issue date	2006-08-01(xsd:dateTime)
bibo:doi	10.1016/j.gene.2006.03.010
bibo:pmid	16781089
has license	els-covid
sha1sum (hex)	4518e94c8d782b510f4cd492c26736cd41bb1d75
schema:url	https://doi.org/10.1016/j.gene.2006.03.010
resource representing a document's title	ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
has PubMed Central identifier	PMC7125734
has PubMed identifier	16781089
schema:publication	Gene
resource representing a document's body	covid:4518e94c8d782b510f4cd492c26736cd41bb1d75#body_text
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