About: Infectious agents associated with diarrhoea in neonatal foals in central Kentucky: A comprehensive molecular study

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About: Infectious agents associated with diarrhoea in neonatal foals in central Kentucky: A comprehensive molecular study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Infectious agents associated with diarrhoea in neonatal foals in central Kentucky: A comprehensive molecular study
Creator	Leutenegger, C Elam, J Estrada, M Slovis, N
source	Medline; PMC
abstract	REASONS FOR PERFORMING STUDY: Diarrhoea caused by infectious agents is common in foals but there is no comprehensive molecular work‐up of the relative prevalence of common agents and appearance of coinfections. OBJECTIVES: To determine the prevalence of 9 infectious agents in gastrointestinal (GI)‐diseased and healthy foals with ages ranging from 1 to 20 weeks of age and to what degree coinfections are associated with clinical signs of GI disease. STUDY DESIGN: Retrospective controlled observational study. METHODS: The population consisted of 88 Thoroughbred foals aged 2 days to 17 weeks born on 32 different studfarms in Kentucky. Healthy (n = 37) and GI‐diseased (n = 51) foals were identified based on clinical presentation. Faecal samples were analysed for 9 infectious agents by real‐time PCR: equine rotavirus, equine coronavirus, Clostridium difficile toxins A & B, Neorickettsia risticii, Clostridium perfringens alpha toxin, Lawsonia intracellularis, Rhodococcus equi, Cryptosporidium spp., and Salmonella spp. Salmonella was also cultured from overnight selenite enrichment broth. RESULTS: The prevalence of infectious pathogens under study was between 0% (Lawsonia intracellularis) and 34.6% (equine rotavirus). The overall prevalence for any infectious agent was 63.2% in the GI‐diseased group and 43.2% in the healthy group. Coinfections were significantly more frequent in the sick group (15 monoinfections vs. 22 coinfections) than in the healthy group (12 vs. 4, respectively, P = 0.0002). Six of the 8 infectious agents were associated with the GI‐diseased group, the other 2 were not (equine coronavirus and R. equi). CONCLUSIONS: The use of panels rather than individual tests in combination with quantitative toxin gene analysis enables detection of coinfections significantly associated with risk of disease. Several infectious diseases previously not tested for or considered unimportant were found at high prevalence and require further investigation.
has issue date	2013-08-30(xsd:dateTime)
bibo:doi	10.1111/evj.12119
bibo:pmid	23773143
has license	no-cc
sha1sum (hex)	45283a0e87513eef9e66e7f031c6b1d571b10927
schema:url	https://doi.org/10.1111/evj.12119
resource representing a document's title	Infectious agents associated with diarrhoea in neonatal foals in central Kentucky: A comprehensive molecular study
has PubMed Central identifier	PMC7163618
has PubMed identifier	23773143
schema:publication	Equine Vet J
resource representing a document's body	covid:45283a0e87513eef9e66e7f031c6b1d571b10927#body_text
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