About: Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks

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About: Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks
Creator	Clayton, Emma Minogue, Shane Waugh, Mark
Source	Elsevier; Medline; PMC
abstract	Abstract The four mammalian phosphatidylinositol 4-kinases modulate inter-organelle lipid trafficking, phosphoinositide signalling and intracellular vesicle trafficking. In addition to catalytic domains required for the synthesis of PI4P, the phosphatidylinositol 4-kinases also contain isoform-specific structural motifs that mediate interactions with proteins such as AP-3 and the E3 ubiquitin ligase Itch, and such structural differences determine isoform-specific roles in membrane trafficking. Moreover, different permutations of phosphatidylinositol 4-kinase isozymes may be required for a single cellular function such as occurs during distinct stages of GPCR signalling and in Golgi to lysosome trafficking. Phosphatidylinositol 4-kinases have recently been implicated in human disease. Emerging paradigms include increased phosphatidylinositol 4-kinase expression in some cancers, impaired functioning associated with neurological pathologies, the subversion of PI4P trafficking functions in bacterial infection and the activation of lipid kinase activity in viral disease. We discuss how the diverse and sometimes overlapping functions of the phosphatidylinositol 4-kinases present challenges for the design of isoform-specific inhibitors in a therapeutic context.
has issue date	2013-07-31(xsd:dateTime)
bibo:doi	10.1016/j.plipres.2013.04.002
bibo:pmid	23608234
has license	els-covid
sha1sum (hex)	459d33b82e3a5a073d8608efc547f62a09fd7896
schema:url	https://doi.org/10.1016/j.plipres.2013.04.002
resource representing a document's title	Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks
has PubMed Central identifier	PMC3989048
has PubMed identifier	23608234
schema:publication	Progress in Lipid Research
resource representing a document's body	covid:459d33b82e3a5a073d8608efc547f62a09fd7896#body_text
is schema:about of	named entity 'MEMBRANE TRAFFICKING' named entity 'Emerging' named entity 'pathologies' named entity 'modulate' named entity 'trafficking' named entity 'SIGNALING NETWORKS' named entity 'DIVERSE' named entity 'ORGANELLE' named entity 'HOW' named entity 'SINGLE' named entity 'FUNCTIONING' named entity 'MAMMALIAN' named entity 'VIRAL DISEASE' named entity 'ACTIVATION' named entity 'HAVE' named entity 'PROTEINS' named entity 'GPCR' named entity 'INTER-' named entity 'VESICLE TRAFFICKING' named entity 'RECENTLY' named entity 'LIPID TRAFFICKING' named entity 'MAMMALIAN' named entity 'LIPID KINASE ACTIVITY' named entity 'CHALLENGES' named entity 'BACTERIAL INFECTION' named entity 'DIFFERENT' named entity 'ITCH' named entity 'INHIBITORS' named entity 'PHOSPHATIDYLINOSITOL' named entity 'KINASES' named entity 'FUNCTIONS' named entity 'MEMBRANE TRAFFICKING' named entity 'GOLGI' named entity 'PHOSPHATIDYLINOSITOL' named entity 'IMPAIRED' named entity 'TRAFFICKING' named entity 'THERAPEUTIC' named entity 'ROLES' named entity 'INTERACTIONS' named entity 'OVERLAPPING' named entity 'MEDIATE' named entity 'MODULATE' named entity 'SIGNALLING' named entity 'CELLULAR FUNCTION' named entity 'AP-3' named entity 'CONTAIN' named entity 'DISCUSS' named entity 'KINASES' named entity 'SYNTHESIS' named entity 'INCLUDE' named entity 'CANCERS' named entity 'ISOFORM' named entity 'STRUCTURAL' named entity 'PHOSPHATIDYLINOSITOL 4-KINASE' named entity 'DESIGN' named entity 'MAY BE' named entity 'INTRACELLULAR VESICLE' named entity 'DETERMINE' named entity 'OCCURS DURING' named entity 'PRESENT' named entity 'PARADIGMS' named entity 'LYSOSOME' named entity 'PATHOLOGIES' named entity 'CATALYTIC' named entity 'ISOZYMES' named entity 'INCREASED' named entity 'SPECIFIC' named entity 'LIPID SIGNALING' named entity 'NEUROLOGICAL' named entity 'STRUCTURAL MOTIFS' named entity 'ASSOCIATED WITH' named entity 'E3 UBIQUITIN LIGASE' named entity 'EXPRESSION' named entity 'STAGES' named entity 'MODULATORS' named entity 'CONTEXT' named entity 'REQUIRED' named entity 'DISTINCT' named entity 'HUMAN DISEASE'

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