About: Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

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About: Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling
Creator	Butts, Thomas Elphick, Maurice Jones, Alexandra Luis, Alfonso Mirabeau, Olivier Moghul, Ismail Yañ Ez-Guerra, Zampronio, Cleidiane Zhong, Xingxing
source	Medline; PMC
abstract	Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour. However, there are challenges associated with determination of orthology between neuropeptides in different taxa. Orthologs of vertebrate neuropeptide-Y (NPY) known as neuropeptide-F (NPF) have been identified in protostome invertebrates, whilst prolactin-releasing peptide (PrRP) and short neuropeptide-F (sNPF) have been identified as paralogs of NPY/NPF in vertebrates and protostomes, respectively. Here we investigated the occurrence of NPY/NPF/PrRP/sNPF-related signalling systems in a deuterostome invertebrate phylum – the Echinodermata. Analysis of transcriptome/genome sequence data revealed loss of NPY/NPF-type signalling, but orthologs of PrRP-type neuropeptides and sNPF/PrRP-type receptors were identified in echinoderms. Furthermore, experimental studies revealed that the PrRP-type neuropeptide pQDRSKAMQAERTGQLRRLNPRF-NH(2) is a potent ligand for a sNPF/PrRP-type receptor in the starfish Asterias rubens. Our findings indicate that PrRP-type and sNPF-type signalling systems are orthologous and originated as a paralog of NPY/NPF-type signalling in Urbilateria.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.7554/elife.57640
bibo:pmid	32579512
has license	cc-by
sha1sum (hex)	474cfb8afd4eec5a1cf246fdc34289092286047f
schema:url	https://doi.org/10.7554/elife.57640
resource representing a document's title	Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling
has PubMed Central identifier	PMC7314547
has PubMed identifier	32579512
schema:publication	eLife
resource representing a document's body	covid:474cfb8afd4eec5a1cf246fdc34289092286047f#body_text
is schema:about of	named entity 'regulators' named entity 'signalling systems' named entity 'phylum' named entity 'orthology' named entity 'studies' named entity 'NPY' named entity 'revealed' named entity 'HERE' named entity 'ORTHOLOGOUS' named entity 'RECEPTOR' named entity 'ANALYSIS' named entity 'PRRP' named entity 'NPY' named entity 'transcriptome' named entity 'Neuropeptide' named entity 'receptor' named entity 'neuropeptides' named entity 'signalling systems' named entity 'Analysis' named entity 'Orthologs' named entity 'ligands' named entity 'neuropeptide' named entity 'protostomes' named entity 'NPY' named entity 'ligand' named entity 'neuropeptides' named entity 'echinoderms' named entity 'transcriptome' named entity 'Asterias rubens' named entity 'peptide' named entity 'vertebrates' named entity 'NPF' named entity 'cognate' named entity 'Echinodermata' named entity 'invertebrate' named entity 'Echinoderms' named entity 'neuropeptide' named entity 'clade' named entity 'NPY' named entity 'Urbilateria' named entity 'NPY' named entity 'intron' named entity 'intron' named entity 'Bilateria' named entity 'orthologs' named entity 'Phylogenetic' named entity 'Drosophila melanogaster' named entity 'echinoderm' named entity 'genomic sequence' named entity 'cDNA' named entity 'neuropeptides' named entity 'proline' named entity 'peptides' named entity 'cognate' named entity 'peptides' named entity 'NPY' named entity 'bilaterian' named entity 'neuropeptide' named entity 'ortholog' named entity 'protostome' named entity 'cell line' named entity 'vertebrate' named entity 'coding sequence' named entity 'evolution' named entity 'apoaequorin' named entity 'pyroglutamate' named entity 'NPF' named entity 'sequence similarity' named entity 'neuropeptides' named entity 'echinoderm' named entity 'Asterias rubens' named entity 'neuropeptides' named entity 'echinoderm'

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