About: Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

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About: Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16
Creator	Aghi, M Chiocca, E Depinho, R Visted, T
Source	Medline; PMC
abstract	Oncolytic herpes simplex viruses (HSVs), in clinical trials for the treatment of malignant gliomas, are assumed to be selective for tumor cells because their replication is strongly attenuated in quiescent cells, but not in cycling cells. Oncolytic selectivity is thought to occur because mutations in viral ICP6 (encoding a viral ribonucleotide reductase function) and/or γ34.5 function are respectively complemented by mammalian ribonucleotide reductase and GADD34, whose genes are expressed in cycling cells. However, it is estimated that only 5–15% of malignant glioma cells are in mitosis at any one time. Therefore, effective replication of HSV oncolytic viruses might be limited to a subpopulation of tumor cells, since at any one time the majority of tumor cells would not be cycling. However, we report that an HSV with defective ICP6 function replicates in quiescent cultured murine embryonic fibroblasts obtained from mice with homozygous p16 deletions. Furthermore, intracranial inoculation of this virus into the brains of p16−/− mice provides evidence of viral replication that does not occur when the virus is injected into the brains of wild-type mice. These approaches provide in vitro and in vivo evidence that ICP6-negative HSVs are ‘molecularly targeted,’ because they replicate in quiescent tumor cells carrying specific oncogene deletions, independent of cell cycle status.
has issue date	2008-03-17(xsd:dateTime)
bibo:doi	10.1038/onc.2008.53
bibo:pmid	18345032
has license	no-cc
sha1sum (hex)	47d51da432b48a0031a32f06e85639781b74abb4
schema:url	https://doi.org/10.1038/onc.2008.53
resource representing a document's title	Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16
has PubMed Central identifier	PMC7100519
has PubMed identifier	18345032
schema:publication	Oncogene
resource representing a document's body	covid:47d51da432b48a0031a32f06e85639781b74abb4#body_text
is schema:about of	named entity 'CELLS' named entity 'tumor cells' named entity 'tumor cells' named entity 'mice' named entity 'function' named entity 'subpopulation' named entity 'replicate' named entity 'HSV' named entity 'REPLICATES' named entity 'HOMOZYGOUS' named entity 'CLINICAL TRIALS' named entity 'THOUGHT' named entity 'MITOSIS' named entity 'HERPES VIRUS' named entity 'DEFECTIVE' named entity 'MALIGNANT GLIOMA' named entity 'NEGATIVE' named entity 'CYCLING' named entity 'SUBPOPULATION' named entity 'LIMITED' named entity 'SPECIFIC' named entity 'DOES NOT' named entity 'CELL CYCLE' named entity 'CELLS' named entity 'REPLICATION' named entity 'EMBRYONIC' named entity 'RIBONUCLEOTIDE REDUCTASE' named entity 'EVIDENCE OF' named entity 'OCCUR' named entity 'REPORT' named entity 'MUTATIONS' named entity 'SELECTIVE' named entity '80%' named entity 'TARGETED' named entity 'INTRACRANIAL' named entity 'MAJORITY' named entity 'DEFECTIVE' named entity 'MICE' named entity 'MAMMALIAN' named entity 'REPLICATE' named entity 'BRAINS' named entity 'EVIDENCE' named entity 'ESTIMATED' named entity 'IN VIVO' named entity 'HERPES SIMPLEX VIRUSES' named entity 'GENES' named entity 'GENETIC MUTATIONS' named entity 'MIGHT BE' named entity 'P16' named entity 'OBTAINED' named entity 'ATTENUATED' named entity 'CARRYING' named entity 'FUNCTION' named entity 'THEIR' named entity 'IN VITRO' named entity 'HOMOZYGOUS' named entity 'ASSUMED' named entity 'VIRUS' named entity 'ONCOLYTIC' named entity 'P16' named entity 'VIRAL REPLICATION' named entity 'ONE TIME' named entity 'PROVIDE' named entity 'REPLICATES' named entity 'EXPRESSED' named entity 'CULTURED' named entity 'MALIGNANT GLIOMAS' named entity 'BUT' named entity 'ONCOLYTIC' named entity 'APPROACHES' named entity 'VIRAL' named entity 'GLIOMA CELLS' named entity 'ONCOGENE' named entity 'PROVIDES' named entity 'MURINE' named entity 'ONCOLYTIC VIRUSES' named entity 'GADD34' named entity 'TUMOR CELLS'

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