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About:
ElectroSens Platform with a Polyelectrolyte-Based Carbon Fiber Sensor for Point-of-Care Analysis of Zn in Blood and Urine
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
ElectroSens Platform with a Polyelectrolyte-Based Carbon Fiber Sensor for Point-of-Care Analysis of Zn in Blood and Urine
Creator
Kalmykov, Evgeniy
Kosareva, Ekaterina
Nikitina, Anna
Nikolaev, Konstantin
Orlova, Olga
Pantiukhin, Igor
Shavronskaya, Daria
Skalny, Anatoly
Skorb, Ekaterina
Stekolshchikova, Anna
Zenkin, Artemiy
Source
Medline; PMC
abstract
[Image: see text] In this paper, we describe an electrochemical sensing platform—ElectroSens—for the detection of Zn based on self-assembled polyelectrolyte multilayers on the carbon fiber (CF) electrode surface. The CF-extended surface facilitates the usage of a small volume electrochemical cell (1 mL) without stirring. This approach allows making a low-cost three-electrode platform. Working electrode modification with layer-by-layer assembly of polyethyleneimine (PEI), poly(sodium 4-styrenesulfonate) (PSS), and mercury nitrate layers eliminates solution toxicity and provides stable stripping voltammetry measurements. The stable, robust, sustainable, and even reusable Ag/AgCl reference electrode consists of adsorbed 32 PEI-KCl/PSS-KCl bilayers on the CF/silver paste separated from the outer solution by a polyvinyl chloride membrane. The polyelectrolyte-based sensor interface prevents adsorption of protein molecules from biological liquids on the CF surface that leads to a sensitivity increase of up to 2.2 μA/M for Zn(2+) detection and provides a low limit of detection of 4.6 × 10(–8) M. The linear range for Zn detection is 1 × 10(–7) to 1 × 10(–5) M. A portable potentiostat connected via wireless to a smartphone with an android-based software is also provided. The ElectroSens demonstrates reproducibility and repeatability of data for the detection of Zn in blood and urine without the digestion step.
has issue date
2020-07-21
(
xsd:dateTime
)
bibo:doi
10.1021/acsomega.0c02279
bibo:pmid
32775900
has license
no-cc
sha1sum (hex)
498e9f31daa202a16bbcfd66864963162be520de
schema:url
https://doi.org/10.1021/acsomega.0c02279
resource representing a document's title
ElectroSens Platform with a Polyelectrolyte-Based Carbon Fiber Sensor for Point-of-Care Analysis of Zn in Blood and Urine
has PubMed Central identifier
PMC7408235
has PubMed identifier
32775900
schema:publication
ACS Omega
resource representing a document's body
covid:498e9f31daa202a16bbcfd66864963162be520de#body_text
is
schema:about
of
named entity 'detection'
named entity 'surface'
named entity 'DIGESTION'
named entity 'UP TO'
named entity 'POLY'
named entity 'LAYERS'
named entity 'KCL'
named entity 'SENSING'
named entity 'PLATFORM'
named entity 'POLYVINYL CHLORIDE'
named entity 'REFERENCE ELECTRODE'
named entity 'OUTER'
named entity 'PASTE'
named entity 'ELECTRODE'
named entity 'PLATFORM'
named entity 'POLYELECTROLYTE'
named entity 'BASED'
named entity 'detection'
named entity 'robust'
named entity 'electrochemical'
named entity 'measurements'
named entity 'connected'
named entity 'detection'
named entity 'electrode'
named entity 'bismuth'
named entity 'KCl'
named entity 'Zakharchuk'
named entity 'electrode'
named entity 'surface'
named entity 'Urine'
named entity 'stripping voltammetry'
named entity 'electrochemical'
named entity '2.2'
named entity 'KCl'
named entity 'layer-by-layer assembly'
named entity 'toxicity'
named entity 'electrode'
named entity 'sodium'
named entity 'Carbon Fiber'
named entity 'surface'
named entity 'protein'
named entity 'sensor'
named entity 'matrix effect'
named entity 'DI water'
named entity 'electrodes'
named entity 'hexahydrate'
named entity 'carrier mobility'
named entity 'spectra'
named entity 'organic molecules'
named entity 'polymers'
named entity 'monohydrate'
named entity 'room temperature'
named entity 'organic solvents'
named entity 'biosensors'
named entity 'Czech Republic'
named entity 'nitrogen'
named entity 'mercury'
named entity 'wt %'
named entity 'deionized (DI) water'
named entity 'potassium ions'
named entity 'electrochemical'
named entity 'polymers'
named entity 'electrode'
named entity 'electroanalysis'
named entity 'urine samples'
named entity 'harmonic number'
named entity 'adsorbed'
named entity 'mercury ions'
named entity '1 mL'
named entity 'cloud database'
named entity 'zinc'
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