About: Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2

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About: Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2 Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2
Creator	Tang, Wen Tian-Yang, Gao Wang, Xiao-Jing Wang, Ying-Ai Zhao, Zhao, Yun-Xue
source	Elsevier; Medline; PMC
abstract	Abstract The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2–6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.
has issue date	2017-05-31(xsd:dateTime)
bibo:doi	10.1016/s1875-5364(17)30059-6
bibo:pmid	28558874
has license	els-covid
sha1sum (hex)	4a0245e89f0e0e1c3ed5dac4dc5793c761b99e87
schema:url	https://doi.org/10.1016/s1875-5364%2817%2930059-6
resource representing a document's title	Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2
has PubMed Central identifier	PMC7130034
has PubMed identifier	28558874
schema:publication	Chinese Journal of Natural Medicines
resource representing a document's body	covid:4a0245e89f0e0e1c3ed5dac4dc5793c761b99e87#body_text
is schema:about of	named entity 'MEDICINES' named entity 'EFFECTS' named entity 'flavonoids' named entity '2095' named entity 'Anti-aging' named entity 'evaluated' named entity 'Gong' named entity 'anti-aging' named entity 'Identification' named entity 'HPLC' named entity 'DAD' named entity 'THEIR' named entity 'CHINESE' named entity 'FLAVANONES' named entity 'FRUITS' named entity 'CODE' named entity '282' named entity 'TONSILLITIS' named entity '2BS' named entity 'COUPLING' named entity 'KNOWN' named entity 'DETECTED' named entity 'MAY BE' named entity 'ITS' named entity 'DIPLACONE' named entity 'FACTOR' named entity 'ENTERITIS' named entity 'INDICATED' named entity 'FLAVONOIDS' named entity 'RESULTS' named entity 'H 2' named entity 'PAULOWNIA' named entity 'ANTI-AGING' named entity 'SEP.' named entity 'ADDITION' named entity 'CELLS' named entity 'NATURAL RESOURCE' named entity 'NUMBER' named entity 'LUNG CANCER' named entity 'INDUCED' named entity 'NATURAL' named entity 'FRUITS' named entity '2 O' named entity 'CHINESE' named entity 'IDENTIFICATION' named entity 'GONG' named entity 'TONG' named entity 'JOURNAL ' named entity 'OUR' named entity 'ISOLATED' named entity 'ESI-MS' named entity 'LIPOPHILIC' named entity 'WAS A' named entity '926' named entity 'DYSENTERY' named entity 'PAULOWNIA' named entity '2BS' named entity 'INDUCED' named entity 'HPLC' named entity 'NEW C' named entity 'EFFECTS' named entity 'IN VITRO' named entity 'TREATMENT' named entity 'SUBSTITUENT' named entity 'EVALUATED' named entity 'FLAVONOIDS' named entity 'ESI-MS' named entity 'CELLS' named entity 'A549 CELLS' named entity 'ETC.' named entity 'WORDS' named entity 'HERBAL MEDICINE' named entity 'CHARACTER' named entity 'USED' named entity 'IDENTIFIED' named entity 'DAD'

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