About: Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats

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About: Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats
Creator	Xu, Xiaoqing Bible, Jesse Gilligan, James Li, Jiliang Mehta, Nozer Miller, Christopher Vignery, Agnès Zhang, Qing Carlson Scholz, Jodi
source	Medline; PMC
abstract	Mechanical ablation of bone marrow in young rats induces rapid but transient bone growth, which can be enhanced and maintained for three weeks by the administration of parathyroid hormone (PTH). Additionally, marrow ablation, followed by PTH treatment for three months leads to increased cortical thickness. In this study, we sought to determine whether PTH enhances bone formation after marrow ablation in aged rats. Aged rats underwent unilateral femoral marrow ablation and treatment with PTH or vehicle for four weeks. Both femurs from each rat were analyzed by X-ray and pQCT, then analyzed either by microCT, histology or biomechanical testing. Marrow ablation alone induced transient bone formation of low abundance that persisted over four weeks, while marrow ablation followed by PTH induced bone formation of high abundance that also persisted over four weeks. Our data confirms that the osteo-inducive effect of marrow ablation and the additive effect of marrow ablation, followed by PTH, occurs in aged rats. Our observations open new avenues of investigations in the field of tissue regeneration. Local marrow ablation, in conjunction with an anabolic agent, might provide a new platform for rapid site-directed bone growth in areas of high bone loss, such as in the hip and wrist, which are subject to fracture.
has issue date	2012-12-05(xsd:dateTime)
bibo:doi	10.3390/cells1041168
bibo:pmid	24710549
has license	cc-by
sha1sum (hex)	4a64ef9057367aec43ce6b8a40e9bb0c9587fdf4
schema:url	https://doi.org/10.3390/cells1041168
resource representing a document's title	Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats
has PubMed Central identifier	PMC3901151
has PubMed identifier	24710549
schema:publication	Cells
resource representing a document's body	covid:4a64ef9057367aec43ce6b8a40e9bb0c9587fdf4#body_text
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