About: The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

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About: The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
Creator	De Jong, Menno Campbell, Harry Rudan, Igor Gelemanović, Andrea Kirin, Mirna Kolčić, Ivana Patarčić, Inga Polašek, Ozren Theodoratou, Evropi Baillie, Kenneth
source	Medline; PMC
abstract	Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The IL4-TLR2-CCL2 axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.
has issue date	2015-11-03(xsd:dateTime)
bibo:doi	10.1038/srep16119
bibo:pmid	26524966
has license	cc-by
sha1sum (hex)	4a7c2c60763755a14783f728e9b4cde8bf899f09
schema:url	https://doi.org/10.1038/srep16119
resource representing a document's title	The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
has PubMed Central identifier	PMC4630784
has PubMed identifier	26524966
schema:publication	Sci Rep
resource representing a document's body	covid:4a7c2c60763755a14783f728e9b4cde8bf899f09#body_text
is schema:about of	named entity 'SIGNIFICANT' named entity 'SCALE' named entity 'HIGHLY' named entity 'RISK FACTOR' named entity 'TRANSLATION' named entity 'ALMOST' named entity 'RISK OF BIAS' named entity 'LOW' named entity 'TARGET' named entity 'TO REDUCE' named entity 'BUT' named entity 'CCL2' named entity 'INTERESTING' named entity 'POOLED' named entity 'AXIS' named entity 'EVIDENCE' named entity 'TLR2' named entity 'LARGER' named entity 'IL4' named entity 'USE' named entity 'GENETIC FACTORS' named entity 'identified' named entity 'collaborations' named entity 'infectious diseases' named entity 'BUILD' named entity 'DETECTED' named entity 'ADHERE TO' named entity 'STRONG' named entity 'ADDITIONAL' named entity 'CLINICAL' named entity 'BASED' named entity 'SUBSET' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISM' named entity 'STUDIES' named entity 'RESPIRATORY TRACT' named entity 'INFECTIOUS DISEASES' named entity 'SYSTEMATIC REVIEW' named entity 'META' named entity 'FIELD' named entity 'PROVIDE' named entity 'ORDER' named entity 'CREDIBILITY' named entity 'HIGHEST' named entity 'RESEARCH' named entity 'OF EVIDENCE' named entity 'STUDY DESIGN' named entity 'IL4 GENE' named entity '1.66' named entity 'TLR2 GENE' named entity 'SYNOPSIS' named entity 'ROLE' named entity 'HOST' named entity '0.88' named entity 'COLLABORATIONS' named entity 'IDENTIFIED' named entity 'ASSOCIATION' named entity 'FUTURE' named entity 'RESPIRATORY INFECTIONS' named entity 'COULD BE' named entity 'TUBERCULOSIS' named entity 'WASTE' named entity 'CONCLUSION' named entity '5B1' covid:arg/4a7c2c60763755a14783f728e9b4cde8bf899f09 named entity 'axis' named entity 'evidence-based' named entity 'provide' named entity 'One' named entity 'Future studies' named entity 'bias' named entity 'gene' named entity 'However'

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