About: HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation

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About: HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation
Creator	Wang, Hui Yang, Bo Wang, Jie Liu, Lu Gao, Zhitao Guo, Zhixiang Liu, Yanzi Lu, Guangjian Ma, Lingling Song, Di Yang, Shuai Zhang, Chenguang
source	PMC
abstract	The roles of autophagy in viral infection are complicated. While autophagy has been shown to function in host antiviral defense by eliminating intracellular viruses and regulating adaptive immunity, several viruses have evolved molecular mechanisms to get benefits from it. The deltaretrovirus human T-cell leukemia virus type-1 (HTLV-1) has been reported to profit its replication from enhancing autophagosome accumulation. Here, we reported that HLA-DMB (generally referred to here as DMB), the beta chain of the non-classical MHC-II protein HLA-DM, had strong expression in HTLV-1-transformed T-cell lines and could be induced in Hela, PMA-differentiated THP1 (PMA-THP1) or primary human monocytes by HTLV-1 infection. Immunoblot and real-time PCR assays demonstrated that overexpression of DMB decreased HTLV-1 protein expression while the knockdown of DMB increased HTLV-1 protein expression. Immunoblot and confocal microscopy assays indicated that overexpression of DMB decreased HTLV-1 induced autophagosome accumulation while the knockdown of DMB yielded the opposite effects. Coimmunoprecipitation and immunoprecipitation experiments suggested DMB interacted with autophagy-related gene (ATG) 7 and increased the acetylation of ATG7. Taken together, these results suggested DMB modulated HTLV-1 protein expression through regulation of autophagosome accumulation and our findings suggested a new mechanism by which the host cells defended against HTLV-1 infection.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1038/s41598-017-14882-z
bibo:pmid	29089548
has license	cc-by
sha1sum (hex)	4aa092956fea94f9487d129b4a05a8704b73d0fc
schema:url	https://doi.org/10.1038/s41598-017-14882-z
resource representing a document's title	HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation
has PubMed Central identifier	PMC5663917
has PubMed identifier	29089548
schema:publication	Sci Rep
resource representing a document's body	covid:4aa092956fea94f9487d129b4a05a8704b73d0fc#body_text
is schema:about of	named entity 'replication' named entity 'DMB' named entity 'complicated' named entity 'DMB' named entity 'DMB' named entity 'ATG7' named entity 'HLA-DMB' named entity 'REFERRED TO' named entity 'OPPOSITE' covid:arg/4aa092956fea94f9487d129b4a05a8704b73d0fc named entity 'ANTIVIRAL' named entity 'DMB' named entity 'REGULATION' named entity 'NON-' named entity 'THESE' named entity 'EXPERIMENTS' named entity 'HOST CELLS' named entity 'RESTRICTS' named entity 'HUMAN T-CELL LEUKEMIA' named entity 'MOLECULAR' named entity 'DECREASED' named entity 'PROTEIN EXPRESSION' named entity 'COIMMUNOPRECIPITATION' named entity 'THP1' named entity 'PROTEIN ' named entity 'EFFECTS' named entity 'CHAIN' named entity 'IMMUNOBLOT' named entity 'ACETYLATION' named entity 'STRONG' named entity 'OPEN' named entity 'LEUKEMIA VIRUS' named entity 'LEUKEMIA VIRUS' named entity 'ADAPTIVE IMMUNITY' named entity 'OUR' named entity 'NEW' named entity 'ENHANCING' named entity 'HUMAN T-CELL LEUKEMIA' named entity 'ACETYLATION' named entity 'VIRUS TYPE' named entity 'PROTEIN EXPRESSION' named entity 'GENE' named entity 'FINDINGS' named entity 'EVOLVED' named entity 'CELL LINES' named entity 'MHC-II' named entity 'HELA' named entity 'HTLV-1 INFECTION' named entity 'DELTARETROVIRUS' named entity 'TAKEN' named entity 'HTLV-1' named entity 'HERE' named entity 'ATG7' named entity 'REAL-TIME PCR ' named entity 'CLASSICAL' named entity 'VIRUSES' named entity 'IMMUNOPRECIPITATION' named entity 'INTERACTED' named entity 'AUTOPHAGOSOME' named entity 'T-CELL' named entity 'OVEREXPRESSION' named entity 'COULD BE' named entity 'BENEFITS' named entity 'INDICATED' named entity 'MODULATED' named entity 'HUMAN MONOCYTES' named entity 'ROLES' named entity 'HOST' named entity 'INCREASED' named entity 'AUTOPHAGY'

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