About: Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine

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About: Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine
Creator	Wu, Qian Yan, Fang Li, Zhong Hu, Yongting Ji, Wenhui Lei, Wenxin Li, Xuying Qiu, Jianyang Shi, Xiumin Zhao, Yujun
topic	covid:4bae83e2441c3738d96e49c21c9be0a4c85b4a92#this
source	PMC
abstract	The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or pVAX1-16N alone) or multivalently (combination of the three different plasmids, pVAX1-16S1/M/N). A prime-boost immunization protocol against IBV was developed. Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once. Antibody titers of the chickens immunized with pVAX1-16S1/M/N were much higher than those of the monovalent groups (p < 0.01). A protective rate up to 90% was observed in the pVAX1-16S1/M/N group. The serum antibody titers in the prime-boost birds were significantly higher than those of the multivalent DNA vaccine group (p < 0.01) but not significantly different compared to the inactivated vaccine group at 49 days of age. Additionally, the prime-boost group also showed the highest level of IBV-specific cellular proliferation compared to the monovalent groups (p < 0.01) but no significant difference was found compared to the multivalent DNA vaccine group, and the prime-boost group completely protected from followed viral challenge.
has issue date	2013-03-24(xsd:dateTime)
bibo:doi	10.4142/jvs.2013.14.1.53
bibo:pmid	23388447
has license	cc-by-nc
sha1sum (hex)	4bae83e2441c3738d96e49c21c9be0a4c85b4a92
schema:url	https://doi.org/10.4142/jvs.2013.14.1.53
resource representing a document's title	Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine
has PubMed Central identifier	PMC3615232
has PubMed identifier	23388447
schema:publication	J Vet Sci
resource representing a document's body	covid:4bae83e2441c3738d96e49c21c9be0a4c85b4a92#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/4bae83e2441c3738d96e49c21c9be0a4c85b4a92
is schema:about of	named entity 'PLASMID' named entity 'ENCODING' named entity 'PROTOCOL' named entity 'FOUND' named entity 'PRIME' named entity 'INVESTIGATED' named entity 'M PROTEIN' named entity 'COMPARED' named entity 'CHICKENS' named entity 'ANTIBODY TITERS' named entity 'immunized' named entity 'plasmid' named entity 'compared' named entity 'higher' named entity 'boosted' named entity 'virus' named entity 'CELLULAR PROLIFERATION' named entity 'SPECIFIC' named entity 'UP TO' named entity 'PLASMIDS' named entity 'DIFFERENT' named entity 'CHALLENGE' named entity 'BIRDS' named entity 'GROUPS' named entity 'IMMUNIZATION' named entity 'EFFICACY' named entity 'DNA VACCINE' named entity 'HIGHEST' named entity '0.01' named entity 'DNA' named entity 'BOOST' named entity '90%' named entity 'IMMUNIZED' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'TWICE' named entity 'DIFFERENCE' named entity 'SIGNIFICANT' named entity 'VIRAL' named entity 'DAYS' named entity 'LEVEL' named entity 'AGE' named entity 'OBSERVED' named entity 'HIGHER' named entity 'BUT' named entity 'VETERINARY SCIENCE' named entity 'RATE' named entity 'MUCH' named entity 'GROUP' named entity '28P' named entity 'COMPLETELY' named entity 'INACTIVATED VACCINE' named entity 'SERUM' named entity 'PROTEIN ' named entity 'FOLLOWED' covid:arg/4bae83e2441c3738d96e49c21c9be0a4c85b4a92 named entity 'monovalent' named entity '16M' named entity 'DNA vaccine' named entity 'prime-boost' named entity 'efficacy' named entity 'multivalent' named entity '49 days' named entity 'serum' named entity 'Antibody' named entity 'prime-boost' named entity 'plasmids' named entity 'IBV' named entity 'plasmid' named entity 'DNA vaccine' named entity 'immunized'

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