About: The Process of Wrapping Virus Revealed by a Force Tracing Technique and Simulations

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Process of Wrapping Virus Revealed by a Force Tracing Technique and Simulations
Creator	Wang, Hanzhong Cai, Mingjun Wang, Hongda Liu, Shuheng Pan, Yangang Shan, Yuping Wang, Xianqiao Zhang, Fuxian Zhang, Liuyang Cai, M Liu, S Pan, Y Shan, Y Wang, Zhang, Zhang, F
source	PMC
abstract	Viral entry into the host cell is the first step of virus infection; however, its dynamic process via endocytosis remains largely elusive. Here, the force tracing technique and single particle simulation are combined to investigate the invagination of single human enterovirus 71 (HEV71, a positive single‐stranded RNA virus that is associated with hand, foot, and mouth disease) via cell membranes during its host cell entry. The experimental results reveal that the HEV71 invaginates in membrane vesicles at a force of 58 ± 16 pN, a duration time of 278 ± 68 ms. The simulation further shows that the virus can reach a partially wrapped state very fast, then the upper surface of the virus is covered by the membrane traveling over a long period of time. Combining the experiment with the simulation, the mechanism of membrane wrapping of virus is uncovered, which provides new insights into how the cell is operated to initiate the endocytosis of virus.
has issue date	2017-04-26(xsd:dateTime)
bibo:doi	10.1002/advs.201600489
bibo:pmid	28932658
has license	cc-by
sha1sum (hex)	4bd3a768f65bf203f8ac6e26fc5c82b373c868bd
schema:url	https://doi.org/10.1002/advs.201600489
resource representing a document's title	The Process of Wrapping Virus Revealed by a Force Tracing Technique and Simulations
has PubMed Central identifier	PMC5604396
has PubMed identifier	28932658
schema:publication	Adv Sci (Weinh)
resource representing a document's body	covid:4bd3a768f65bf203f8ac6e26fc5c82b373c868bd#body_text
is schema:about of	named entity 'INVAGINATION' named entity 'TECHNIQUE' named entity 'MEMBRANE' named entity 'MECHANISM' named entity 'SIMULATION' named entity 'UPPER SURFACE' named entity 'THE CELL' named entity 'REACH' named entity 'PARTIALLY' named entity 'WRAPPING' named entity 'FAST' named entity 'SINGLE' named entity 'COMBINING' named entity 'POSITIVE' named entity 'COVERED BY' named entity 'elusive' named entity 'wrapped' named entity 'foot' named entity 'Combining' named entity 'cell' named entity 'wrapping' named entity 'Technique' named entity 'VIRUS' named entity 'SIMULATIONS' covid:arg/4bd3a768f65bf203f8ac6e26fc5c82b373c868bd named entity 'REVEAL' named entity 'PARTICLE' named entity 'ENDOCYTOSIS' named entity 'FOOT' named entity 'PROVIDES' named entity 'LARGELY' named entity 'NEW' named entity 'TRAVELING' named entity 'VIRUS INFECTION' named entity 'PERIOD OF TIME' named entity 'ENTRY' named entity 'TO INVESTIGATE' named entity 'HAND' named entity 'RNA VIRUS' named entity 'ASSOCIATED WITH' named entity 'ITS' named entity 'HOST CELL' named entity 'VIRAL ENTRY' named entity 'VIRUS' named entity 'HOW' named entity 'FIRST STEP' named entity 'STATE' named entity 'FORCE' named entity 'REVEALED' named entity 'WRAPPING' named entity 'PAPER' named entity 'PROCESS' named entity 'LONG' named entity 'HUMAN ENTEROVIRUS 71' named entity 'FORCE' named entity 'COMBINED' named entity 'UNCOVERED' named entity 'VESICLES' named entity 'DURATION TIME' named entity 'EXPERIMENT' named entity 'WRAPPED' named entity 'HERE' named entity 'EXPERIMENTAL RESULTS' named entity 'TECHNIQUE' named entity 'PROCESS' named entity 'MS.'

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