About: Antigenic variation of porcine transmissible gastroenteritis virus detected by monoclonal antibodies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antigenic variation of porcine transmissible gastroenteritis virus detected by monoclonal antibodies
Creator	Hohdatsu, T Eiguchi, Y Ide, S Matumoto', M Tsuchimot0, M Yamagishi, H
source	PMC
abstract	Mouse myeloma cells (SP2/O) were fused with spleen cells from BALB/c mice immunized with detergent-solubilized antigen of purified virus, and 21 monoclonal (MC) antibodies reactive in enzyme-linked immunosorbent assay with the TO-163 strain of porcine transmissible gastroenteritis (TGE) virus were obtained. Of these MC antibodies, 14, 6 and 1 were IgG1, IgG2a and IgM, respectively. All of the MC antibodies contained light chains of the kappa type. Of these MC antibodies, 8 were found to have neutralization (NT) activity against the TO-163 strain. Comparison of 7 strains of TGE virus by NT tests using our panel of MC antibodies confirmed their close antigenic relationships, but also revealed the occurence of distinct antigenic differences. These results suggest that there may be at least 6 different epitopes involved in NT reaction on the virion of the TO-163 strain. This notion was confirmed by the competitive binding assay.
has issue date	2002-11-12(xsd:dateTime)
bibo:doi	10.1016/0378-1135(87)90003-4
bibo:pmid	2444027
has license	no-cc
sha1sum (hex)	4c04431830f520a349d5535bb15326c2553207b9
schema:url	https://doi.org/10.1016/0378-1135%2887%2990003-4
resource representing a document's title	Antigenic variation of porcine transmissible gastroenteritis virus detected by monoclonal antibodies
has PubMed Central identifier	PMC7117515
has PubMed identifier	2444027
schema:publication	Vet Microbiol
resource representing a document's body	covid:4c04431830f520a349d5535bb15326c2553207b9#body_text
is schema:about of	named entity 'Antibodies' named entity 'Gastroenteritis' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'IDE' named entity 'MONOCLONAL ANTIBODIES' named entity 'ANTIGENIC VARIATION' named entity 'MONOCLONAL ANTIBODIES' named entity 'VET' named entity '124' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'DETECTED' named entity '1987' named entity '115' named entity 'ANTIGENIC VARIATION' named entity 'DETECTED' named entity 'monoclonal antibodies' named entity 'transmissible' named entity 'homologous' named entity 'polyclonal antibodies' named entity 'antibodies' named entity 'kidney cells' named entity 'intravenous' named entity 'diffusion' named entity 'antibodies' named entity 'carbonate' named entity 'antibodies' named entity 'antibodies' named entity 'antigenic variation' named entity 'microplate' named entity 'horseradish peroxidase' named entity 'antibodies' named entity 'kidney' named entity 'antibodies' named entity 'immunoglobulins' named entity '10:1' named entity 'myeloma' named entity 'peroxidase' named entity 'CPK' named entity 'room temperature' named entity 'virus' named entity 'Japan' named entity 'antibodies' named entity 'epitopes' named entity 'Corning Glass Works' named entity 'H202' named entity 'competitive binding' named entity 'phosphate' named entity 'antibodies' named entity 'envelope protein' named entity 'ml-1' named entity 'enzyme-linked immunosorbent assay' named entity 'TPB' named entity 'antibodies' named entity 'U.S.A' named entity 'IgG2b' named entity 'peplomer' named entity 'ascitic fluid' named entity 'antibody' named entity 'antibody' named entity 'pig' named entity 'CPK' named entity 'ascitic fluid' named entity 'clones' named entity 'pristane' named entity 'antigen' named entity 'Kanagawa' named entity 'streptomycin' named entity 'virus' named entity 'neutralization tests' named entity 'pH 7' named entity 'titer' named entity 'titer' named entity 'microplate' named entity 'spleen' named entity 'antibody' named entity 'centrifuged'

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