About: Direct comparison of dietary portfolio vs statin on C-reactive protein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Direct comparison of dietary portfolio vs statin on C-reactive protein
Creator	Li, T Connelly, P Emam, A Faulkner, D Josse, A Josse, R Leiter, L Marchie, A Parker, T Singer, W De Souza, R Jenkins, Dja Kendall, Cwc Wong, Jmw
topic	covid:4cbec9b2e4cf4f86d9a820df458613ca4a61f246#this
source	Medline; PMC
abstract	BACKGROUND: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known. OBJECTIVE: To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk. METHODS: In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g/1000 kcal), soy protein (21.4 g/1000 kcal), viscous fibers (9.8 g/1000 kcal), and almonds (14 g/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4. RESULTS: Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (>3.5 mg/l) were excluded, CRP was reduced similarly on both statin, −16.3±6.7% (n=23, P=0.013) and dietary portfolio, −23.8±6.9% (n=25, P=0.001) but not the control, 15.3±13.6% (n=28, P=0.907). The percentage CRP change from baseline on the portfolio treatment (n=25) was greater than the control (n=28, P=0.004) but similar to statin treatment (n=23, P=0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment. CONCLUSIONS: A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin.
has issue date	2005-05-18(xsd:dateTime)
bibo:doi	10.1038/sj.ejcn.1602152
bibo:pmid	15900306
has license	no-cc
sha1sum (hex)	4cbec9b2e4cf4f86d9a820df458613ca4a61f246
schema:url	https://doi.org/10.1038/sj.ejcn.1602152
resource representing a document's title	Direct comparison of dietary portfolio vs statin on C-reactive protein
has PubMed Central identifier	PMC7073252
has PubMed identifier	15900306
schema:publication	Eur J Clin Nutr
resource representing a document's body	covid:4cbec9b2e4cf4f86d9a820df458613ca4a61f246#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/4cbec9b2e4cf4f86d9a820df458613ca4a61f246
is schema:about of	named entity 'COMMUNICATION' named entity 'C-REACTIVE PROTEIN' named entity 'cholesterol' named entity 'almonds' named entity 'data' named entity 'CRP' named entity 'dose' named entity 'order' named entity 'CRP' named entity 'percentile' named entity 'BACKGROUND' named entity 'COMPLETED' named entity 'EFFECT' named entity 'REDUCE' named entity 'SIGNIFICANT' named entity 'STARTING' named entity 'DOSE' named entity 'COMPARISON' named entity 'PLANT STEROLS' named entity 'DIET' named entity 'CHANGE IN' named entity 'MG%' named entity 'ANTI-INFLAMMATORY' named entity 'HYPERLIPIDEMIC' named entity 'HIGH' named entity 'FAT DIET' named entity 'OUTPATIENTS' named entity 'LEVELS' named entity 'GREATER THAN' named entity 'FASTING' named entity '0.001' named entity 'STUDIES' named entity 'TREATMENTS' covid:arg/4cbec9b2e4cf4f86d9a820df458613ca4a61f246 named entity 'DIETARY' named entity 'LOWERING' named entity 'SUBJECTS' named entity 'ORDER' named entity 'SERUM CHOLESTEROL' named entity 'PROTEIN ' named entity 'MARKEDLY' named entity 'KNOWN' named entity 'STATIN' named entity 'REDUCING' named entity 'REPORTED' named entity '876' named entity '907' named entity 'HYDROXY' named entity 'OBJECTIVE' named entity 'RANDOM' named entity 'SERUM CRP' named entity 'FIBERS' named entity 'BIOMARKER' named entity 'DATA' named entity 'EFFICACY' named entity 'CHANGE FROM BASELINE' named entity 'CONCLUSIONS' named entity 'TO COMPARE' named entity 'NO TREATMENT' named entity 'BIOMARKERS' named entity 'ORIGINAL' named entity 'DIRECT' named entity 'STATIN' named entity 'DIETARY' named entity 'COMPLETE' named entity 'DIETS'

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