About: Golgi inCOGnito: From vesicle tethering to human disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Golgi inCOGnito: From vesicle tethering to human disease
Creator	Lupashin, Vladimir Taher, Farhana D'souza, Zinia Souza, Zinia
Source	Elsevier; Medline; PMC
abstract	The Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) family, controls several aspects of cellular homeostasis by orchestrating retrograde vesicle traffic within the Golgi. The COG complex interacts with all key players regulating intra-Golgi trafficking, namely SNAREs, SNARE-interacting proteins, Rabs, coiled-coil tethers, and vesicular coats. In cells, COG deficiencies result in the accumulation of non-tethered COG-complex dependent (CCD) vesicles, dramatic morphological and functional abnormalities of the Golgi and endosomes, severe defects in N- and O- glycosylation, Golgi retrograde trafficking, sorting and protein secretion. In humans, COG mutations lead to severe multi-systemic diseases known as COG-Congenital Disorders of Glycosylation (COG-CDG). In this report, we review the current knowledge of the COG complex and analyze COG-related trafficking and glycosylation defects in COG-CDG patients.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1016/j.bbagen.2020.129694
bibo:pmid	32730773
has license	no-cc
sha1sum (hex)	4dc09789321a102a56bafa7306512426cdf35006
schema:url	https://doi.org/10.1016/j.bbagen.2020.129694
resource representing a document's title	Golgi inCOGnito: From vesicle tethering to human disease
has PubMed Central identifier	PMC7384418
has PubMed identifier	32730773
schema:publication	Biochim Biophys Acta Gen Subj
resource representing a document's body	covid:4dc09789321a102a56bafa7306512426cdf35006#body_text
is schema:about of	named entity 'cells' named entity 'family' named entity 'key' named entity 'patients' named entity 'tethering' named entity 'COMPLEX' named entity 'TRAFFIC' named entity 'DEPENDENT' named entity 'MORPHOLOGICAL' named entity 'COG' named entity 'CCD' named entity 'severe' named entity 'humans' named entity 'retrograde' named entity 'Golgi' named entity 'secretion' named entity 'tethering' named entity 'homeostasis' named entity 'controls' named entity 'cellular' named entity 'Disorders' named entity 'Rods' named entity 'COG' named entity 'dependent' named entity 'Golgi' named entity 'Journal' named entity 'Helical' named entity 'vesicle' named entity 'COG' named entity 'Tethering' named entity 'complex function' named entity 'Antisense therapy' named entity 'bovine' named entity 'molecular mechanism' named entity 'Gene therapy' named entity 'heterozygous' named entity 'membrane lipids' named entity 'BFA' named entity 'glycosylation' named entity 'intravenous' named entity 'GBF1' named entity 'BFA' named entity 'Golgi' named entity 'COG7' named entity 'arginine' named entity 'Atg proteins' named entity 'enzyme activity' named entity 'integral membrane proteins' named entity 'sialylation' named entity 'cellular physiology' named entity 'Golgi cisternae' named entity 'glycosylation' named entity 'exocyst' named entity 'SNAREs' named entity 'substrate' named entity 'COG7' named entity 'COG4' named entity 'wild-type' named entity 'vesicular' named entity 'mannose' named entity 'phospholipid' named entity 'FRAP' named entity 'SNARE complex' named entity 'Golgi' named entity 'vacuole' named entity 'gene therapy' named entity 'vesicle' named entity 'autophagy' named entity 'trans-Golgi' named entity 'point mutation' named entity 'Rift Valley fever' named entity 'STX6' named entity 'gastrointestinal' named entity 'photobleaching' named entity 'mutation' named entity 'mammalian cells' named entity 'COG8' named entity 'hypoglycemia'

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