About: Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genes

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About: Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genes
Creator	Ghanchi, Asghar Hasan#, Hasan, Zahra Jamil, Iffat Kanji, Zahra Khanum, Safina Kiran, Iqbal Mahmood, Saba Masood, Nasir, Bushra Nasir, Najia Razzak, Akbar Shahid, Nosheen Syed, Faisal
source	MedRxiv
abstract	COVID-19 caused by SARS-CoV-2 manifests as a range of symptoms. Understanding the molecular mechanisms responsible for immuno-pathogenesis of disease is important for treatment and management of COVID-19. We examined host transcriptomes in moderate and severe COVID-19 cases with a view to identifying pathways that affect its progression. RNA extracted from whole blood of COVID-19 cases was analysed by microarray analysis. Moderate and severe cases were compared with healthy controls and differentially regulated genes (DEGs) categorized into cellular pathways. DEGs in COVID-19 cases were mostly related to host immune activation and cytokine signaling, pathogen uptake, host defenses, blood and vasculature genes, and SARS-CoV-2- and other virus- affected pathways. The DEGs in these pathways were increased in severe compared with moderate cases. In a severe COVID-19 patient with an unfavourable outcome we observed dysregulation of genes in platelet homeostasis and cardiac conduction and fibrin clotting with disease progression.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.1101/2020.06.18.20132571
has license	medrxiv
sha1sum (hex)	4dfce27adaf1b717e4fb3cf4b4fad592784c8fc7
schema:url	https://doi.org/10.1101/2020.06.18.20132571
resource representing a document's title	Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genes
resource representing a document's body	covid:4dfce27adaf1b717e4fb3cf4b4fad592784c8fc7#body_text
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