About: Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits

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About: Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits
Creator	Lee, Kwong-Man Qin, Ling Huang, Le Pei, Duanqing Liu, Ying Chen, Yang Wang, Xiaohong Zhang, Peng Lei, Ming Yao, Dong Wang, Xinluan Chen, Shihui Cheng, Chun-Yiu Gong, He Huang, Yanping Liu, Wai-Ching Liu, Zhong Pan, Xiaohua Peng, Jiang Wang, Daping Xiao, Deming Xie, Xinhui Xiong, Jiangyi Yao, Xinsheng Zheng, Lizhen Zheng, Yongping Feng, Jian Griffith, James
Source	Elsevier; Medline; PMC
abstract	Abstract Steroid-associated osteonecrosis (SAON) may lead to joint collapse and subsequent joint replacement. Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after surgical core-decompression (CD) to prevent femoral head collapse in a bipedal SAON animal model using emu (a large flightless bird). The underlying mechanism on SAON was evaluated using a well-established quadrupedal rabbit model. Fifteen emus were established with SAON, and CD was performed along the femoral neck for the efficacy study. In this CD bone defect, a P/T scaffold with icaritin (P/T/I group) or without icaritin (P/T group) was implanted while no scaffold implantation was used as a control. For the mechanistic study in rabbits, the effects of icaritin and composite scaffolds on bone mesenchymal stem cells (BMSCs) recruitment, osteogenesis, and anti-adipogenesis were evaluated. Our efficacy study showed that P/T/I group had the significantly lowest incidence of femoral head collapse, better preserved cartilage and mechanical properties supported by more new bone formation within the bone tunnel. For the mechanistic study, our in vitro tests suggested that icaritin enhanced the expression of osteogenesis related genes COL1α, osteocalcin, RUNX2, and BMP-2 while inhibited adipogenesis related genes C/EBP-ß, PPAR-γ, and aP2 of rabbit BMSCs. Both P/T and P/T/I scaffolds were demonstrated to recruit BMSCs both in vitro and in vivo but a higher expression of migration related gene VCAM1 was only found in P/T/I group in vitro. In conclusion, both efficacy and mechanistic studies show the potential of a bioactive composite porous P/T scaffold incorporating icaritin to enhance bone defect repair after surgical CD and prevent femoral head collapse in a bipedal SAON emu model.
has issue date	2015-08-31(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2015.04.038
bibo:pmid	25968462
has license	els-covid
sha1sum (hex)	4e977b54f5d3d4141b92d5cd273fbdf77c125fba
schema:url	https://doi.org/10.1016/j.biomaterials.2015.04.038
resource representing a document's title	Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits
has PubMed Central identifier	PMC7111223
has PubMed identifier	25968462
schema:publication	Biomaterials
resource representing a document's body	covid:4e977b54f5d3d4141b92d5cd273fbdf77c125fba#body_text
is schema:about of	named entity 'STEROID' named entity 'ICARITIN' named entity 'EFFECTS' named entity 'BONE' named entity 'RABBIT' named entity 'PERFORMED' named entity 'MIGRATION' named entity 'CONCLUSION' named entity 'USED' named entity 'MECHANISTIC STUDY' named entity 'EPIMEDIUM' named entity 'FIFTEEN' named entity 'COMPOSITE' named entity 'METABOLITE' named entity 'DERIVED' named entity 'PRESERVED' named entity 'POLY' named entity 'LOWEST' named entity 'EVALUATED' named entity 'MECHANICAL PROPERTIES' named entity 'TESTS' named entity 'POTENTIAL' named entity 'SUSTAINED RELEASE' named entity 'EFFICACY' named entity 'CONTROL' named entity 'GROUP' named entity 'RECRUITMENT' named entity 'OSTEOCALCIN' named entity 'OSTEONECROSIS' named entity 'ICARITIN' named entity 'adipogenesis' named entity 'scaffolds' named entity 'genes' named entity 'collapse' named entity 'performed' named entity 'tests' named entity 'scaffolds' named entity 'aP2' named entity 'TCP' named entity 'bipedal' named entity 'mechanistic' named entity 'ASSOCIATED' named entity 'EMUS' named entity 'PREVENTION OF' named entity 'STEROID' named entity 'HIGHER' named entity 'LEAD' named entity 'FLIGHTLESS' named entity 'LARGE' named entity 'SUPPORTED' named entity 'UNDERLYING' named entity 'PPARG' named entity 'OSTEONECROSIS' named entity 'MECHANISTIC STUDIES'

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