About: Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Creator	Wang, Li-San Sell, Christian Cohen, Justin Donahue, Greg Nativio, Raffaella Torres, Claudio Tuzer, Ferit Yetkin, Emre Cohen, J Bd, Gregory Berger, Shelley Bonini, Nancy Crowe, Elizabeth Ep, Crowe Fb, Johnson Gosai, Sager Gregory, Brian Johnson, F Leung, Yuk Morgan, David Nm, Bonini Sj, Gosai Sl, Berger Tropea, Daniela Vickers, James Wang, Nativio Yy, Leung
Source	PMC
abstract	Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome using RNA sequencing. Senescence was induced in human fetal astrocytes by transient oxidative stress. Brain-expressed genes, including those involved in neuronal development and differentiation, were downregulated in senescent astrocytes. Remarkably, several genes indicative of astrocytic responses to injury were also downregulated, including glial fibrillary acidic protein and genes involved in the processing and presentation of antigens by major histocompatibility complex class II proteins, while pro-inflammatory genes were upregulated. Overall, our findings suggest that senescence-related changes in the function of astrocytes may impact the pathogenesis of age-related brain disorders.
has issue date	2016-08-31(xsd:dateTime)
bibo:doi	10.3389/fnagi.2016.00208
bibo:pmid	27630559
has license	cc-by
sha1sum (hex)	4ea1d124972eda4c488d6446f88964f60bed47fc
schema:url	https://doi.org/10.3389/fnagi.2016.00208
resource representing a document's title	Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
has PubMed Central identifier	PMC5005348
has PubMed identifier	27630559
schema:publication	Front Aging Neurosci
resource representing a document's body	covid:4ea1d124972eda4c488d6446f88964f60bed47fc#body_text
is schema:about of	named entity 'IMPACT' named entity 'FUNCTION' named entity 'TRANSIENT' named entity 'RISK FACTOR' named entity 'ANTIGENS' named entity 'INCLUDING' named entity 'OVERALL' named entity 'BRAIN' named entity 'PROCESSING' named entity 'TISSUES' named entity 'FEATURE' named entity 'SUGGEST' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II' named entity 'PATHOGENESIS' named entity 'INDUCED' named entity 'INVOLVED' named entity 'OUR' named entity 'NEURONAL DEVELOPMENT' named entity 'BIOLOGY' named entity 'ASTROCYTIC' named entity 'THEIR' named entity 'RESPONSES' named entity 'GENE EXPRESSION' named entity 'A MAJOR' named entity 'SENESCENCE' named entity 'NEURODEGENERATIVE DISEASE' named entity 'FETAL' named entity 'pathogenesis' named entity 'RNA' named entity 'Senescence' named entity 'investigated' named entity 'Senescence' covid:arg/4ea1d124972eda4c488d6446f88964f60bed47fc named entity 'PRO-' named entity 'SENESCENT' named entity 'GENES' named entity 'ASTROCYTES' named entity 'INVESTIGATED' named entity 'CELLULAR SENESCENCE' named entity 'HUMAN' named entity 'USING' named entity 'UPREGULATED' named entity 'CHANGES' named entity 'ACCOMPANYING' named entity 'TRANSCRIPTOME' named entity 'ASTROCYTES' named entity 'HUMAN' named entity 'INDUCED' named entity 'OXIDATIVE STRESS' named entity 'BETTER' named entity 'AGE' named entity 'PROTEIN ' named entity 'NEURODEGENERATIVE DISORDERS' named entity 'ALTERED' named entity 'DEVELOPMENT AND DIFFERENTIATION'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software