About: Innate sensing of oxidation-specific epitopes in health and disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Innate sensing of oxidation-specific epitopes in health and disease
Creator	Binder, Christoph Papac-Milicevic, Nikolina Witztum, Joseph
source	Medline; PMC
abstract	Ageing, infections and inflammation result in oxidative stress that can irreversibly damage cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of these deleterious consequences that not only alters lipid function but also leads to the formation of neo-self epitopes — oxidation-specific epitopes (OSEs) — which are present on dying cells and damaged proteins. OSEs represent endogenous damage-associated molecular patterns that are recognized by pattern recognition receptors and the proteins of the innate immune system, and thereby enable the host to sense and remove dangerous biological waste and to maintain homeostasis. If this system is dysfunctional or overwhelmed, the accumulation of OSEs can trigger chronic inflammation and the development of diseases, such as atherosclerosis and age-related macular degeneration. Understanding the molecular components and mechanisms that are involved in this process will help to identify individuals with an increased risk of developing chronic inflammation, and will also help to indicate novel modes of therapeutic intervention. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2016.63) contains supplementary material, which is available to authorized users.
has issue date	2016-06-27(xsd:dateTime)
bibo:doi	10.1038/nri.2016.63
bibo:pmid	27346802
has license	no-cc
sha1sum (hex)	4ebe445ce9d252e8d0935d58b262728704d73133
schema:url	https://doi.org/10.1038/nri.2016.63
resource representing a document's title	Innate sensing of oxidation-specific epitopes in health and disease
has PubMed Central identifier	PMC7097710
has PubMed identifier	27346802
schema:publication	Nat Rev Immunol
resource representing a document's body	covid:4ebe445ce9d252e8d0935d58b262728704d73133#body_text
is schema:about of	named entity 'OXIDATION' named entity 'Oxidative' named entity 'responses' named entity 'oxygen' named entity 'generated' named entity 'Within' named entity 'oxygen' named entity 'organisms' named entity 'processes' named entity 'stability' named entity 'functions' named entity 'ROS' named entity 'energy' named entity 'organisms' named entity 'endoplasmic reticulum' named entity 'hydroxyl radicals' named entity 'accumulation' named entity 'oxidative burst' named entity 'HEALTH AND DISEASE' named entity 'REACTIONS' named entity 'TOXINS' named entity 'GENERATION' named entity 'RESULTS' named entity 'STABILITY' named entity 'ENERGY PRODUCTION' named entity 'IDEA' named entity 'SECONDARY' named entity 'DIFFERENTIATION' named entity 'BIOMOLECULES' named entity 'PHYSIOLOGICAL PROCESSES' named entity 'PHAGOCYTOSIS' named entity 'EXTRACELLULAR' named entity 'PRODUCTION' named entity 'PROLIFERATION' named entity 'ROS' named entity 'CELLULAR METABOLISM' named entity 'UNRESOLVED' named entity 'HARMFUL' named entity 'DAMAGE' named entity 'SPECIES' named entity 'INCLUDE' named entity 'VARIOUS' named entity 'INDUCTION' named entity 'AMOUNTS' named entity 'CELL' named entity 'CAUSED BY' named entity 'NORMAL' named entity 'IRRADIATION' named entity 'USAGE' named entity 'RNA' named entity 'SPECIFIC' named entity 'EPITOPES' named entity 'ORGANISMS' named entity 'EUKARYOTIC' named entity 'DNA' named entity 'EXTRACELLULAR TRAPS' named entity 'SENSING' named entity 'HORMESIS' named entity 'CELLULAR' named entity 'THESE' named entity 'GREATLY' named entity 'DEPEND' named entity 'LIPIDS' named entity 'MODULATION' named entity 'CONDITIONS' named entity 'OXIDATIVE STRESS' named entity 'OXY' named entity 'SUPEROXIDE' named entity 'EFFECTS' named entity '2C4' named entity 'ANTIOXIDANT' named entity 'LIMITED BY' named entity 'DEATH' named entity 'IMPAIR' named entity 'RECENTLY' named entity 'REACTIVE' named entity 'OXIDATIVE BURST' named entity 'HIGH' named entity 'MECHANISMS'

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