About: The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation
Creator	Sosnik, Alejandro Buznyk, Oleksiy Griffith, May Papapavlou, Georgia Buznyk, Papapavlou El-Fiqi, Ahmed Islam, Mohammad Leung, Brendan Mm, Islam Patra, Hirak
topic	covid:4ed809f5b348f735454271411a4bef01bfad0734#this
Source	Medline; PMC
abstract	Biomaterials are now being used or evaluated clinically as implants to supplement the severe shortage of available human donor organs. To date, however, such implants have mainly been developed as scaffolds to promote the regeneration of failing organs due to old age or congenital malformations. In the real world, however, infection or immunological issues often compromise patients. For example, bacterial and viral infections can result in uncontrolled immunopathological damage and lead to organ failure. Hence, there is a need for biomaterials and implants that not only promote regeneration but also address issues that are specific to compromised patients, such as infection and inflammation. Different strategies are needed to address the regeneration of organs that have been damaged by infection or inflammation for successful clinical translation. Therefore, the real quest is for multifunctional biomaterials with combined properties that can combat infections, modulate inflammation, and promote regeneration at the same time. These strategies will necessitate the inclusion of methodologies for management of the cellular and signaling components elicited within the local microenvironment. In the development of such biomaterials, strategies range from the inclusion of materials that have intrinsic anti-inflammatory properties, such as the synthetic lipid polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC), to silver nanoparticles that have antibacterial properties, to inclusion of nano- and micro-particles in biomaterials composites that deliver active drugs. In this present review, we present examples of both kinds of materials in each group along with their pros and cons. Thus, as a promising next generation strategy to aid or replace tissue/organ transplantation, an integrated smart programmable platform is needed for regenerative medicine applications to create and/or restore normal function at the cell and tissue levels. Therefore, now it is of utmost importance to develop integrative biomaterials based on multifunctional biopolymers and nanosystem for their practical and successful clinical translation.
has issue date	2016-09-09(xsd:dateTime)
bibo:doi	10.3389/fbioe.2016.00071
bibo:pmid	27668213
has license	cc-by
sha1sum (hex)	4ed809f5b348f735454271411a4bef01bfad0734
schema:url	https://doi.org/10.3389/fbioe.2016.00071
resource representing a document's title	The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation
has PubMed Central identifier	PMC5016531
has PubMed identifier	27668213
schema:publication	Front Bioeng Biotechnol
resource representing a document's body	covid:4ed809f5b348f735454271411a4bef01bfad0734#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/4ed809f5b348f735454271411a4bef01bfad0734
is schema:about of	named entity 'ANTI-INFLAMMATORY' named entity 'QUEST' named entity 'biomaterials' named entity 'damage' named entity 'evaluated' named entity 'scaffolds' named entity 'Thus' named entity 'age' named entity 'real' named entity 'materials' named entity 'Anti-inflammatory' named entity 'Biotechnology' named entity 'BIOENGINEERING' named entity 'DONOR ORGANS' named entity 'STRATEGIES' named entity 'PROPERTIES' named entity 'SCAFFOLDS' named entity 'RANGE' named entity 'TISSUE' named entity 'DIFFERENT' named entity 'OLD AGE' named entity 'CELLULAR' named entity 'BEING' named entity 'TRANSPLANTATION' named entity 'THESE' named entity 'ORGAN FAILURE' named entity 'LEVELS' named entity 'USED' named entity 'AID' named entity 'METHODOLOGIES' named entity 'DRUGS' named entity 'DATE' named entity 'INTEGRATED' named entity 'ANTIBACTERIAL' named entity 'REGENERATIVE MEDICINE' named entity 'ELICITED' named entity 'TRANSLATION' named entity 'INFECTION' named entity 'ACTIVE' named entity 'GENERATION' named entity 'MANAGEMENT' named entity 'LIPID' named entity 'SILVER NANOPARTICLES' named entity 'CONGENITAL MALFORMATIONS' named entity 'SPECIFIC' named entity 'AVAILABLE' named entity 'PLATFORM' named entity 'PARTICLES' named entity 'LEAD' named entity 'REPLACE' named entity 'SIGNALING' named entity 'LOCAL' named entity 'ANTI-INFLAMMATORY' named entity 'FAILING' named entity 'DELIVER' named entity 'WORLD' named entity 'NEEDED' named entity 'INCLUSION' named entity 'PROMOTE' named entity 'PATIENTS' named entity 'HAVE' named entity 'CLINICAL' named entity 'GROUP' named entity 'CREATE' named entity '2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE' named entity 'NEED FOR' named entity 'EXAMPLE' named entity 'INFECTIONS' named entity 'INTRINSIC' named entity 'CLINICAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software