About: Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation

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About: Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation
Creator	Lee, Jun Choi, Yu Kang, Jin Kim, Sun Shin, Young Eui, \| Hee, \| Hyoung, \| Hyung, \| Jeong, Joo Lee, Bongjin Park, June You, \| Yul, Hong
Source	Medline; PMC
abstract	PC are a main cause of death following HSCT in children. We aimed to evaluate early predictors of mortality in paediatric recipients with PCs. A retrospective observational study of 35 patients with 49 episodes of PI on chest radiography (of 124 patients) who had undergone HSCT at a tertiary university hospital between January 2011 and December 2012 was performed. During follow‐up (median 26.1 months), 15 episodes led to death (30.6%). An aetiologic diagnosis was made by non‐invasive tests in 24 episodes (49.0%) and by adding bronchoalveolar lavage and/or lung biopsy in 7 episodes with diagnostic yield (77.8%, P = .001). Thus, a specific diagnosis was obtained in 63.3% of the episodes. Aetiology identification and treatment modification after diagnosis did not decrease mortality (P = .057, P = .481). However, the number of organ dysfunctions at the beginning of PI was higher in the mortality group, compared to the survivor group (1.7 ± 1.2 vs 0.32 ± 0.59; P = .001). Hepatic dysfunction (OR, 11.145; 95% CI, 1.23 to 101.29; P = .032) and neutropaenia (OR, 10.558; 95% CI, 1.07 to 104.65; P = .044) were independently associated with risk of mortality. Therefore, hepatic dysfunction and neutropaenia are independent early predictors of mortality in HSCT recipients with PCs.
has issue date	2017-10-12(xsd:dateTime)
bibo:doi	10.1111/petr.13062
bibo:pmid	29027353
has license	no-cc
sha1sum (hex)	4f4e9b22eef9a69f2c98833ac60e080ecb0dad31
schema:url	https://doi.org/10.1111/petr.13062
resource representing a document's title	Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation
has PubMed Central identifier	PMC7167723
has PubMed identifier	29027353
schema:publication	Pediatr Transplant
resource representing a document's body	covid:4f4e9b22eef9a69f2c98833ac60e080ecb0dad31#body_text
is schema:about of	covid:arg/4f4e9b22eef9a69f2c98833ac60e080ecb0dad31 named entity 'observational study' named entity 'HSCT' named entity 'neutropaenia' named entity 'follow-up' named entity 'Hepatic dysfunction' named entity 'organ' named entity 'haematopoietic stem cell transplantation' named entity 'prospective study' named entity 'osteopetrosis' named entity 'neutropaenia' named entity 'CMV' named entity 'Fisher's exact test' named entity 'lung problems' named entity 'aetiologies' named entity 'multidrug resistant' named entity 'CMV infection' named entity 'bacteria' named entity 'LBs' named entity 'sputum' named entity 'GVHD' named entity 'antigen test' named entity 'pulmonary function tests' named entity 'laboratory tests' named entity 'ultrasound' named entity 'Statistical analyses' named entity 'antithrombin III' named entity 'pulmonologist' named entity 'hypoxemic' named entity 'medical conditions' named entity 'inotropic' named entity 'tumour necrosis factor-alpha' named entity 'thoracic surgeons' named entity 'log-rank test' named entity 'intravenously injected' named entity 'odds ratio' named entity 'immunosuppressants' named entity 'statistically significant' named entity 'neurological' named entity 'induction therapy' named entity 'aspergillus' named entity 'non-invasive' named entity 'lung problems' named entity 'Logistic regression' named entity 'virus' named entity 'bronchial' named entity 'chest pain' named entity 'serology' named entity 'inflammatory cytokines' named entity 'viral load' named entity 'organ dysfunction' named entity 'tacrolimus' named entity 'odds ratio' named entity 'Institutional review board' named entity 'medical conditions' named entity 'CPR' named entity 't-test' named entity 'oncologist' named entity 'ganciclovir' named entity 'PCR' named entity 'lung disease' named entity 'haematological' named entity 'neutropaenia' named entity 'viral pneumonia' named entity 'targeted therapy' named entity 'HSCT' named entity 'bronchiolitis obliterans' named entity 'Neutrophil'

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