About: Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

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About: Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
Creator	Helenius, Ari Hepojoki, Jussi Kuivanen, Suvi Vapalahti, Olli Balistreri, Giuseppe Smura, Teemu Kallio-Kokko, Hannimari Kallio, Katri Stadelmann, Christine Anastasina, Maria Butcher, Sarah Cantuti-Castelvetri, Ludovico Djannatian, Minou Franz, Jonas Gokce, Ozgun Joensuu, Merja Kaya, Tuğberk Levanov, Lev Meunier, Frédéric Mollenhauer, Brit Ojha, Ravi Pedro, Liliana Simons, Mikael Szirovicza, Leonora Teesalu, Tambet Tobi, Allan Winkler, Martin
source	BioRxiv
abstract	The causative agent of the current pandemic and coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. Understanding how SARS-CoV-2 enters and spreads within human organs is crucial for developing strategies to prevent viral dissemination. For many viruses, tissue tropism is determined by the availability of virus receptors on the surface of host cells2. Both SARS-CoV and SARS-CoV-2 use angiotensin-converting enzyme 2 (ACE2) as a host receptor, yet, their tropisms differ3-5. Here, we found that the cellular receptor neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, which was inhibited by a monoclonal blocking antibody against the extracellular b1b2 domain of NRP1. NRP1 is abundantly expressed in the respiratory and olfactory epithelium, with highest expression in endothelial cells and in the epithelial cells facing the nasal cavity. Neuropathological analysis of human COVID-19 autopsies revealed SARS-CoV-2 infected NRP1-positive cells in the olfactory epithelium and bulb. In the olfactory bulb infection was detected particularly within NRP1-positive endothelial cells of small capillaries and medium-sized vessels. Studies in mice demonstrated, after intranasal application, NRP1-mediated transport of virus-sized particles into the central nervous system. Thus, NRP1 could explain the enhanced tropism and spreading of SARS-CoV-2.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1101/2020.06.07.137802
has license	biorxiv
sha1sum (hex)	4f7b0222cd263f1a6fd0feb00d31468b4915583f
schema:url	https://doi.org/10.1101/2020.06.07.137802
resource representing a document's title	Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
schema:publication	bioRxiv
resource representing a document's body	covid:4f7b0222cd263f1a6fd0feb00d31468b4915583f#body_text
is schema:about of	named entity 'mediated' named entity 'domain' named entity 'ACE2' named entity 'cells' named entity 'neuropilin-1' named entity 'Thus' named entity 'Here' named entity 'capillaries' named entity 'bind' named entity 'tropisms' named entity 'facilitates' named entity 'human organs' named entity 'receptor' named entity 'intranasal' named entity 'revealed' named entity 'olfactory bulb' named entity 'host' named entity 'endothelial cells' named entity 'detected' named entity 'nasal cavity' named entity 'autopsies' named entity 'expression' named entity 'olfactory epithelium' named entity 'SARS-CoV-2' named entity 'infectivity' named entity 'SARS-CoV' named entity 'endothelial cells' named entity 'intranasal' named entity 'olfactory epithelium' named entity 'SARS-CoV-2' named entity 'NRP1' named entity 'NRP1' named entity 'SARS-CoV-2' named entity 'host cells' named entity 'COVID' named entity 'Neuropathological' named entity 'nasal cavity' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity '293T cells' named entity 'infection' named entity 'olfactory bulbs' named entity 'C-terminal' named entity 'potency' named entity 'transmembrane' named entity 'olfactory neuroepithelium' named entity '4a-c' named entity 'encephalitis' named entity 'cell cluster' named entity 'HTLV-1' named entity 'Freund's adjuvant' named entity 'COVID-19' named entity 'NRP1' named entity 'cytomegalovirus' named entity 'ligands' named entity 'NRP1' named entity 'RNA'

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