About: FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients

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About: FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients
Creator	Li, Yan Chen, Liang Han, Xiudi Xing, Xiqian Zhang, Chunxiao
Source	PMC
abstract	BACKGROUND: The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability to predict influenza-related pneumonia, however, is less well-established. METHODS: A total of 693 laboratory-confirmed FluA-p patients diagnosed between Jan 2013 and Dec 2018 and recruited from five teaching hospitals in China were included in the study. The sample included 494 patients in the derivation cohort and 199 patients in the validation cohort. The prediction rule was established based on independent risk factors for 30-day mortality in FluA-p patients from the derivation cohort. RESULTS: The 30-day mortality of FluA-p patients was 19.6% (136/693). The FluA-p score was based on a multivariate logistic regression model designed to predict mortality. Results indicated the following significant predictors (regression statistics and point contributions toward total score in parentheses): blood urea nitrogen > 7 mmol/L (OR 1.604, 95% CI 1.150–4.492, p = 0.040; 1 points), pO(2)/F(i)O(2) ≤ 250 mmHg (OR 2.649, 95% CI 1.103–5.142, p = 0.022; 2 points), cardiovascular disease (OR 3.967, 95% CI 1.269–7.322, p < 0.001; 3 points), arterial PH < 7.35 (OR 3.959, 95% CI 1.393–7.332, p < 0.001; 3 points), smoking history (OR 5.176, 95% CI 2.604–11.838, p = 0.001; 4 points), lymphocytes < 0.8 × 10(9)/L (OR 8.391, 95% CI 3.271–16.212, p < 0.001; 5 points), and early neurominidase inhibitor therapy (OR 0.567, 95% CI 0.202–0.833, p = 0.005; − 2 points). Seven points was used as the cut-off value for mortality risk stratification. The model showed a sensitivity of 0.941, a specificity of 0.762, and overall better predictive performance than the PSI risk class (AUROC = 0.908 vs 0.560, p < 0.001) and the CURB-65 score (AUROC = 0.908 vs 0.777, p < 0.001). CONCLUSIONS: Our results showed that a FluA-p score was easy to derive and that it served as a reliable prediction rule for 30-day mortality in FluA-p patients. The score could also effectively stratify FluA-p patients into relevant risk categories and thereby help treatment providers to make more rational clinical decisions.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1186/s12931-020-01379-z
bibo:pmid	32384935
has license	cc-by
sha1sum (hex)	5118efb1f547ec7051e34bedb6b428380bd91c15
schema:url	https://doi.org/10.1186/s12931-020-01379-z
resource representing a document's title	FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients
has PubMed Central identifier	PMC7206684
has PubMed identifier	32384935
schema:publication	Respir Res
resource representing a document's body	covid:5118efb1f547ec7051e34bedb6b428380bd91c15#body_text
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