About: Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations

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About: Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
Creator	Chen, Feng Fang, Jie Lucas, Rudolf Yang, Guang Zhang, Ping Chen, Li-Ping Deng, Li-Bin Deng, Ya-Jun Fan, Shuan-Liang Liu, Shun-Zhi Qin, Hai-Xia Shen, Chun-Mei Wang, Hong-Dan Wang, Zhen-Yuan Zhu, Bo-Feng
source	Medline; PMC
abstract	OBJECTIVE: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. METHODS: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. RESULTS: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B*4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. CONCLUSION: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.
has issue date	2010-02-01(xsd:dateTime)
bibo:doi	10.1631/jzus.b0900232
bibo:pmid	20104647
has license	green-oa
sha1sum (hex)	535ee77a0ae790653270c324e1db261a5eed1a85
schema:url	https://doi.org/10.1631/jzus.b0900232
resource representing a document's title	Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
has PubMed Central identifier	PMC2816316
has PubMed identifier	20104647
schema:publication	Journal of Zhejiang University SCIENCE B
resource representing a document's body	covid:535ee77a0ae790653270c324e1db261a5eed1a85#body_text
is schema:about of	named entity 'distributions' named entity 'allelic frequencies' named entity 'chain' named entity 'Objective' named entity 'DISTRIBUTIONS' named entity 'ETHNIC MINORITY' named entity 'ALLELES' named entity 'CHINA' named entity 'OBJECTIVE' named entity '114' named entity 'HLA-A' named entity 'DNA TYPING' named entity 'LOCI' named entity 'METHOD' named entity 'HUMAN LEUKOCYTE ANTIGEN' named entity 'METHODS' named entity 'SEQUENCE-BASED TYPING' named entity 'EXPECTATION MAXIMIZATION ALGORITHM' named entity 'CALCULATED' named entity 'HAPLOTYPES' named entity 'ALLELES' named entity 'COUNTING' named entity 'SBT' named entity 'ESTIMATED' named entity 'TO INVESTIGATE' named entity 'FREQUENCIES' named entity 'DIRECT' named entity 'INDIVIDUALS' named entity 'HAPLOTYPES' named entity 'POPULATIONS' named entity 'HLA-A' named entity 'POPULATION' named entity 'ETHNIC MINORITY' named entity 'PERFORMED' named entity 'HEALTHY' named entity 'SOUTHWESTERN' named entity 'USING' named entity 'YUNNAN PROVINCE' named entity 'SELECTED' named entity 'POLYMERASE CHAIN REACTION' named entity 'DISTRIBUTIONS' named entity 'RELATIONSHIP' named entity 'CHINA' named entity 'polymerase' named entity 'Yunnan Province' named entity 'estimated' named entity 'China' named entity 'haplotypes' named entity 'alleles' named entity 'allelic frequencies' named entity 'haplotypes' named entity 'Yunnan Province' named entity 'HLA-A' named entity 'polymerase chain reaction' named entity 'loci' named entity 'expectation maximization algorithm' named entity 'human leukocyte antigen' named entity 'HLA-A' named entity 'locus' named entity 'allele' named entity 'allelic' named entity 'haplotypes' named entity 'Tujia' named entity 'HLA-B*1502' named entity 'polymorphisms' named entity 'loci' named entity 'Yunnan'

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