About: Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
Source	PMC
abstract	The ubiquitin-like protein ISG15 and its conjugation to proteins (ISGylation) are strongly induced by type I interferon. Influenza B virus encodes non-structural protein 1 (NS1B) that binds human ISG15 and provides an appropriate model for determining how ISGylation affects virus replication in human cells. Here using a recombinant virus encoding a NS1B protein defective in ISG15 binding, we show that NS1B counteracts ISGylation-mediated antiviral activity by binding and sequestering ISGylated viral proteins, primarily ISGylated viral nucleoprotein (NP), in infected cells. ISGylated NP that is not sequestered by mutant NS1B acts as a dominant-negative inhibitor of oligomerization of the more abundant unconjugated NP. Consequently formation of viral ribonucleoproteins that catalyse viral RNA synthesis is inhibited, causing decreased viral protein synthesis and virus replication. We verify that ISGylated NP is largely responsible for inhibition of viral RNA synthesis by generating recombinant viruses that lack known ISGylation sites in NP.
has issue date	2016-09-02(xsd:dateTime)
bibo:doi	10.1038/ncomms12754
bibo:pmid	27587337
has license	cc-by
sha1sum (hex)	53fa60a93898a5901b87fe8ad651ac5f75611071
schema:url	https://doi.org/10.1038/ncomms12754
resource representing a document's title	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
has PubMed Central identifier	PMC5025834
has PubMed identifier	27587337
schema:publication	Nat Commun
resource representing a document's body	covid:53fa60a93898a5901b87fe8ad651ac5f75611071#body_text
is schema:about of	named entity 'Cell' named entity 'IFN-β' named entity 'control' named entity 'PROTEIN ' named entity 'EXPERIMENTS' named entity 'FOLLOWED BY' named entity 'TEXT' named entity 'LIKE' named entity 'NP PROTEIN' named entity 'CELLS' named entity 'ANALYZED' named entity 'IFN' named entity 'INFECTED' named entity '232' named entity 'ISG15' named entity 'TREATED' named entity 'INHIBITED' named entity 'RELATED' named entity 'USING' named entity 'ABS' named entity 'HUMAN' named entity '231' named entity 'CONTROL' named entity 'MUTANT' named entity 'SIRNAS' named entity 'INDICATED' named entity 'EFFICIENCY' named entity 'CELL EXTRACTS' named entity 'TREATMENT' named entity 'SIRNA' named entity 'A549 CELLS' named entity 'VIRUS' named entity 'DESCRIBED' named entity 'ENHANCED' named entity 'FIGURES' named entity 'USED' named entity 'DIFFERENT' named entity '28A' named entity 'USP18' named entity 'EITHER' named entity 'siRNA' named entity 'cells' named entity 'Related' named entity 'Knockdown' named entity 'assayed' named entity 'virus' named entity 'siRNA' named entity 'siRNA' named entity 'transfected' named entity 'USP18' named entity 'siRNA' named entity 'siRNAs' named entity 'immunoblots' named entity 'ISG15' named entity 'siRNA' named entity 'siRNA' named entity 'immunoblots' named entity 'IFN' named entity 'ISG15' named entity 'siRNAs' named entity 'USP18' named entity 'ISG15' named entity 'viruses' named entity 'IFN' named entity 'influenza B virus' named entity 'IFN' named entity 'RNPs' named entity 'protein' named entity 'influenza B virus' named entity 'virus' named entity 'immunoblots' named entity 'mRNA' named entity 'influenza A virus' named entity 'mRNA' named entity 'immunoblots' named entity 'virus' named entity 'A549' named entity 'siRNA' named entity 'IFN' named entity 'protein' named entity 'IFN' named entity 'RT-PCR'

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