About: An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
Creator	Cheng, Jun Dieterich, Christoph Eßer, Jacqueline Pahl, André Partridge, Linda Sehgal, Rohan Tain, Luke Weigelt, Carina Grö, Sebastian Stephen, Luke
Source	Elsevier; Medline; PMC
abstract	Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly in the brain and muscle, of diverse long-lived insulin mutants. Strikingly, lifespan extension of insulin mutants is dependent on circSfl, and overexpression of circSfl alone is sufficient to extend the lifespan. Moreover, circSfl is translated into a protein that shares the N terminus and potentially some functions with the full-length Sfl protein encoded by the host gene. Our study demonstrates that insulin signaling affects global circRNA accumulation and reveals an important role of circSfl during aging in vivo.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1016/j.molcel.2020.06.011
bibo:pmid	32592682
has license	no-cc
sha1sum (hex)	54a844a46dd1174b1cbaae25e91f7cdc0f381b2e
schema:url	https://doi.org/10.1016/j.molcel.2020.06.011
resource representing a document's title	An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
has PubMed Central identifier	PMC7318944
has PubMed identifier	32592682
schema:publication	Mol Cell
resource representing a document's body	covid:54a844a46dd1174b1cbaae25e91f7cdc0f381b2e#body_text
is schema:about of	named entity 'induced' named entity 'fruit flies' named entity 'ENCODED' named entity 'OVEREXPRESSION' named entity 'INDUCED' named entity 'INSULIN' named entity 'SUMMARY' named entity 'translated' named entity 'functionally' named entity 'RNAs' named entity 'Lifespan' named entity 'Drosophila' named entity 'diverse species' named entity 'flies' named entity 'gene' named entity 'RNAs' named entity 'Insulin' named entity 'Circular RNA' named entity 'Insulin' named entity 'luminal' named entity 'flies' named entity 'loss-of-function' named entity 'biogenesis' named entity 'exon' named entity 'log rank test' named entity 'protein' named entity 'splice junction' named entity 'catalyzes' named entity 'metabolism' named entity 'clones' named entity '3,5' named entity 'transmembrane domain' named entity 'protein' named entity 'NCBI' named entity 'July 16' named entity 'MHC' named entity 'catalyzes' named entity 'transgenic fly' named entity 'Drosophila' named entity 'rapamycin' named entity 'fruit fly' named entity 'heart tissue' named entity 'exon' named entity 'muscle' named entity 'siRNAs' named entity 'exon' named entity 'OPEN ACCESS' named entity 'flies' named entity 'post-mitotic' named entity 'thoraces' named entity 'peptides' named entity 'genetic modification' named entity 'plasmids' named entity 'polysome' named entity 'Downregulation' named entity 'Drosophila' named entity 'SDS-PAGE' named entity 'circRNA' named entity 'wild-type' named entity 'polysome' named entity 'Egg laying' named entity 'protein' named entity 'endosymbiontic' named entity 'Upregulation' named entity 'SEM' named entity '3,5' named entity 'circRNA' named entity 'flies' named entity 'flies' named entity 'gene' named entity 'insulin' named entity 'exon'

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