About: Serum Metabolomics Revealed the Differential Metabolic Pathway in Calves with Severe Clinical Diarrhea Symptoms

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About: Serum Metabolomics Revealed the Differential Metabolic Pathway in Calves with Severe Clinical Diarrhea Symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serum Metabolomics Revealed the Differential Metabolic Pathway in Calves with Severe Clinical Diarrhea Symptoms
Creator	Cui, Dong-An Huang, Mei-Zhou Wang, Sheng-Yi Hui, Wang Ding, Xue-Zhi Wu, Xiao-Hu Yan, Zuo-Ting
topic	covid:55440af2f714d12349b6896cb3b66aef6d4fae69#this
source	PMC
abstract	SIMPLE SUMMARY: The present study focuses on the metabolic changes in the diarrhea of calves, which are manifested with the following symptoms: a thin water-like stool, cold ears and nose, throbbing bowels, oliguria, a pale or yellowish complexion, a smooth mouth, and a slow pulse. The differential metabolic pathways in calves with diarrhea were screened by metabolomics. There were nine biomarkers in the serum of healthy calves and calves with diarrhea. On the basis of these biomarkers, their associated mineral absorption, protein digestion and absorption, and other metabolic pathways, the targeted regulation of the metabolic differences of calves with diarrhea may contribute to the diagnosis, treatment, and discussion of the mechanism of calf diarrhea. ABSTRACT: The complex etiology, higher morbidity and mortality, poor prognosis, and expensive cost of calf diarrhea have made it a catastrophic disease in the dairy industry. This study aims to assess the biomarkers in calves with diarrhea and to predict the biomarkers related to the pathway. As subjects, nine calves with diarrhea and nine healthy calves were enrolled, according to strict enrollment criteria. The serum metabolites were detected by a liquid chromatographic tandem mass spectrometry (LC-MS/MS), and then analyzed by online multivariate statistical analysis software to further screen the biomarkers. In addition, the biomarkers involved in the metabolic pathways of calves with diarrhea and healthy calves were analyzed. In the serum of calves with diarrhea, nine biomarkers were found to which several biomarkers exhibited a certain relation. Moreover, these biomarkers were involved in important metabolic pathways, including protein digestion and absorption, ABC transporters, aminoacyl-tRNA biosynthesis, mineral absorption, and fatty acid biosynthesis. All these findings suggested that the imbalance of these markers was closely related to the occurrence and development of calf diarrhea. The targeted regulation of metabolic pathways involved in these biomarkers may facilitate the diagnosis, treatment, and discussion of the mechanism of calf diarrhea.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.3390/ani10050769
bibo:pmid	32354125
has license	cc-by
sha1sum (hex)	55440af2f714d12349b6896cb3b66aef6d4fae69
schema:url	https://doi.org/10.3390/ani10050769
resource representing a document's title	Serum Metabolomics Revealed the Differential Metabolic Pathway in Calves with Severe Clinical Diarrhea Symptoms
has PubMed Central identifier	PMC7278412
has PubMed identifier	32354125
schema:publication	Animals (Basel)
resource representing a document's body	covid:55440af2f714d12349b6896cb3b66aef6d4fae69#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/55440af2f714d12349b6896cb3b66aef6d4fae69
is schema:about of	named entity 'BASIS' named entity 'LIKE' named entity 'DIFFERENTIAL' named entity 'THROBBING' named entity 'METABOLOMICS' named entity 'METABOLIC' named entity 'CHANGES' named entity 'CALVES' named entity 'BOWELS' named entity 'biomarkers' named entity 'diarrhea' named entity 'biomarkers' named entity 'diarrhea' named entity 'tryptophan' named entity 'metabolic pathways' named entity 'metabolic pathways' named entity 'diarrhea' named entity 'biomarkers' named entity 'Diarrhea' named entity 'biological information' named entity 'diarrhea' named entity 'butanoic acid' named entity 'serum samples' named entity 'etiology' named entity 'serum samples' named entity 'Chromatographic separation' named entity 'irreplaceable' named entity 'mineral' named entity 'biomarker' named entity 'parasites' named entity 'biomarkers' named entity 'mass spectrometer' named entity 'diarrhea' named entity 'electrospray ionization' named entity 'p-cresol' named entity 'gastrointestinal disorders' named entity 'biomarkers' named entity 'ionization' named entity 'physiological disorders' named entity 'diarrhea' named entity 'capric acid' named entity 'protein digestion' named entity 'Diarrhea' named entity 'proline' named entity 'metabolic pathways' named entity 'biomarkers' named entity 'Milford, MA' named entity '2.1' named entity 'lyophilized' named entity 'serum samples' named entity 'biomarkers' named entity 'diarrhea' named entity 'diarrhea' named entity 'UPLC' named entity 'serum' named entity 'OPLS' named entity 'serum samples' named entity 'p-cresol' named entity 'biomarkers' named entity 'chromatogram' named entity 'People's Republic of China' named entity 'serum' named entity 'pathogen' named entity 'signal pathway' named entity 'biomarkers' named entity 'L-arginine' named entity 'multivariate statistical analysis' named entity 'diarrhea' named entity 'indoxyl sulfate' named entity 'bacteria' named entity 'ionization' named entity 'serum samples' named entity 'serum'

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