About: Altered distribution of mucosal NK cells during HIV infection

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About: Altered distribution of mucosal NK cells during HIV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Altered distribution of mucosal NK cells during HIV infection
Creator	Alter, Galit Carrington, Mary Liu, Qingquan Berger, Christoph Diefenbach, Thomas Dugast, Anne-Sophie Ghebremichael, Musie Kwon, Douglas Sciaranghella, Gaia Sips, Magdalena Deeks, Steven Estes, Jacob Hunt, Peter Martin, Jeffrey
Source	Medline; PMC
abstract	The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) by which they mediate antiviral activity in the gut is unclear. Here we show two distinct subsets of NK cells exist in the gut, one localized to intraepithelial spaces (IEL) and the other to the lamina propria (LP). The frequency of both subsets of NK cells was reduced in chronic infection, whereas IEL NK cells remained stable in spontaneous controllers with protective KIR/HLA genotypes. Both IEL and LP NK cells were significantly expanded in immunologic non-responsive (INR) patients, who incompletely recovered CD4+ T cells on HAART. These data suggest that both IEL and LP NK cells may expand in the gut in an effort to compensate for compromised CD4+ T cell recovery, but that only IEL NK cells may be involved in providing durable control of HIV in the gut,
has issue date	2011-10-12(xsd:dateTime)
bibo:doi	10.1038/mi.2011.40
bibo:pmid	21993602
has license	no-cc
sha1sum (hex)	568fec0df53acc098777e861ab6b824bf22ca3e4
schema:url	https://doi.org/10.1038/mi.2011.40
resource representing a document's title	Altered distribution of mucosal NK cells during HIV infection
has PubMed Central identifier	PMC3740353
has PubMed identifier	21993602
schema:publication	Mucosal Immunol
resource representing a document's body	covid:568fec0df53acc098777e861ab6b824bf22ca3e4#body_text
is schema:about of	named entity 'durable' named entity 'HIV' named entity 'Here' named entity 'NK cells' named entity 'ALTERED' named entity 'LAMINA PROPRIA' named entity 'THESE' named entity 'HIV' named entity 'CHRONIC INFECTION' named entity 'COPY' named entity 'KIR' named entity 'ASSOCIATED' named entity 'INTRAEPITHELIAL' named entity 'RECOVERY' named entity 'HAART' named entity 'MAY BE' named entity 'HERE' named entity 'CONTENT' named entity 'IMMUNOLOGIC' named entity 'DATA' named entity 'CONDITIONS' named entity 'CELLS' named entity 'USERS' named entity 'ACADEMIC' named entity 'MUCOSAL' named entity 'T CELL' named entity 'CD4' named entity 'FREQUENCY' named entity 'DISTINCT' named entity 'STABLE' named entity 'PATHOGENESIS' named entity 'DISTRIBUTION' named entity 'RECOVERED' named entity 'LOCALIZED' named entity 'THE GUT' named entity 'UNCLEAR' named entity 'NK CELLS' named entity 'COMPENSATE' named entity 'CONTROLLERS' named entity 'PURPOSES' named entity 'EFFORT' named entity 'GUT MUCOSA' named entity 'SITE OF' named entity 'MEDIATE' named entity 'EVIDENCE' named entity 'INVOLVED' named entity 'IEL' named entity 'RESEARCH' named entity 'ANTIVIRAL ACTIVITY' named entity 'PROVIDING' named entity 'INCREASING' named entity 'NATURAL KILLER' named entity 'SUGGEST' named entity 'T CELLS' named entity 'EXIST' named entity 'NON-' named entity 'ROLE' named entity 'MAY VIEW' named entity 'PRINT' named entity 'EXPAND' named entity 'PLAY' named entity 'BUT' named entity 'RESPONSIVE' named entity 'INFECTION' named entity 'HUMAN' named entity 'NK CELLS' named entity 'IS A' named entity '28S'

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