About: Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease

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About: Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease
Creator	Dunker, Freeland Sanders, Chris Buchmeier, Michael Derisi, Joseph Franco, Jessica Kistler, Amy Reavill, Drury Ruby, J Stenglein, Mark
source	Medline; PMC
abstract	Inclusion body disease (IBD) is an infectious fatal disease of snakes typified by behavioral abnormalities, wasting, and secondary infections. At a histopathological level, the disease is identified by the presence of large eosinophilic cytoplasmic inclusions in multiple tissues. To date, no virus or other pathogen has been definitively characterized or associated with the disease. Using a metagenomic approach to search for candidate etiologic agents in snakes with confirmed IBD, we identified and de novo assembled the complete genomic sequences of two viruses related to arenaviruses, and a third arenavirus-like sequence was discovered by screening an additional set of samples. A continuous boa constrictor cell line was established and used to propagate and isolate one of the viruses in culture. Viral nucleoprotein was localized and concentrated within large cytoplasmic inclusions in infected cells in culture and tissues from diseased snakes. In total, viral RNA was detected in 6/8 confirmed IBD cases and 0/18 controls. These viruses have a typical arenavirus genome organization but are highly divergent, belonging to a lineage separate from that of the Old and New World arenaviruses. Furthermore, these viruses encode envelope glycoproteins that are more similar to those of filoviruses than to those of other arenaviruses. These findings implicate these viruses as candidate etiologic agents of IBD. The presence of arenaviruses outside mammals reveals that these viruses infect an unexpectedly broad range of species and represent a new reservoir of potential human pathogens.
has issue date	2012-08-14(xsd:dateTime)
bibo:doi	10.1128/mbio.00180-12
bibo:pmid	22893382
has license	cc-by-nc-sa
sha1sum (hex)	571e8706c0aff7482c60e60cad9d1334c917df12
schema:url	https://doi.org/10.1128/mbio.00180-12
resource representing a document's title	Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease
has PubMed Central identifier	PMC3419519
has PubMed identifier	22893382
schema:publication	mBio
resource representing a document's body	covid:571e8706c0aff7482c60e60cad9d1334c917df12#body_text
is schema:about of	named entity 'ARENAVIRUS' named entity 'OUTSIDE' named entity 'GENOME ORGANIZATION' named entity 'SPECIES' named entity 'GENOMIC' named entity 'MAMMALS' named entity 'CONTINUOUS' named entity 'INFECT' named entity 'BOA CONSTRICTOR' named entity 'ESTABLISHED' named entity 'HISTOPATHOLOGICAL' named entity 'FATAL DISEASE' named entity 'REVEALS' named entity 'THESE' named entity 'NEW RESERVOIR' named entity 'FILOVIRUSES' named entity 'SAMPLES' named entity 'VIRUSES' named entity 'WASTING' named entity 'POTENTIAL' named entity 'METAGENOMIC APPROACH' named entity 'USING' named entity 'COMPLETE' named entity 'DE NOVO' named entity 'CULTURE' named entity 'IBD' named entity 'infected' named entity 'secondary' named entity 'candidate' named entity 'These' named entity 'snakes' named entity 'agents' named entity 'Boa' named entity 'Tree' named entity 'BOA' named entity 'TREE' named entity 'IN VITRO CULTURE' covid:arg/571e8706c0aff7482c60e60cad9d1334c917df12 named entity 'FINDINGS' named entity 'ONE OF' named entity 'SNAKES' named entity 'GLYCOPROTEINS' named entity 'BUT' named entity 'CONCENTRATED' named entity 'ARENAVIRUSES' named entity 'RANGE' named entity 'ISOLATE' named entity 'INFECTED' named entity 'CANDIDATE' named entity 'IDENTIFICATION' named entity 'HIGHLY' named entity 'SNAKE' named entity 'ENCODE' named entity 'CELL LINE' named entity 'PATHOGENS' named entity 'INFECTIOUS' named entity 'SECONDARY INFECTIONS' named entity 'DATE' named entity 'ADDITIONAL' named entity 'BELONGING' named entity 'NUCLEOPROTEIN' named entity 'EOSINOPHILIC' named entity 'CASES' named entity 'TOTAL' named entity 'HAVE' named entity 'SCREENING' named entity 'TYPICAL' named entity 'OLD' named entity 'VIRUS' named entity 'RELATED' named entity 'INCLUSION BODY DISEASE' named entity 'PATHOGEN' named entity 'CHARACTERIZATION'

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