About: Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology

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About: Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology
Creator	Wang, Qian Xie, Yingqiu Li, X Wang, Q Xie, Y Amin, A Amin, Amr Li, Xugang Mu, C Mu, Chenglin Sheng, Y Sheng, Yifan
Source	Elsevier; Medline; PMC
abstract	Abstract Rhizoma Polygonati (huangjing in Chinese, 黄精) is an herb-homology-food used as a component of alternative medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain elusive. Here using TCMSP and Swiss Target Prediction databases to sort out the potential targets of the main chemical components and GenCLiP3, NCBI, and GeneCard databases to search for COVID-19 related targets, the chemical compound-target-pathway network was analyzed. Each component was molecularly docked with host cell target angiotensin converting enzyme II, SARS-CoV-2 targets Spike protein, RNA-dependent RNA polymerase, or 3CL hydrolase. Our results showed a higher affinity of the compound diosgenin and (+)-Syringaresinol-O-beta-D-glucoside binding to the three SARS-CoV-2 proteins compared to the other compounds tested. Thus, our data suggest that potential compounds in Rhizoma Polygonati may act on different targets and have a great potential in treatment of COVID-19.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.1016/j.jff.2020.104149
bibo:pmid	32837538
has license	els-covid
sha1sum (hex)	57e5db6e74918d14d385a27383d990b5495c1f59
schema:url	https://doi.org/10.1016/j.jff.2020.104149
resource representing a document's title	Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology
has PubMed Central identifier	PMC7427583
has PubMed identifier	32837538
schema:publication	Journal of functional foods
resource representing a document's body	covid:57e5db6e74918d14d385a27383d990b5495c1f59#body_text
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