About: HoBi-like pestivirus experimental infection in pregnant ewes: Reproductive disorders and generation of persistently infected lambs

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About: HoBi-like pestivirus experimental infection in pregnant ewes: Reproductive disorders and generation of persistently infected lambs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HoBi-like pestivirus experimental infection in pregnant ewes: Reproductive disorders and generation of persistently infected lambs
Creator	Buonavoglia, Canio Decaro, Nicola Mari, Viviana Tempesta, Maria Camero, Michele Losurdo, Michele Larocca, Vittorio Varello, Katia Lucente, Maria Patruno, Giovanni Iulini, Barbara Occhiogrosso, Leonardo Sciarra, Marina
Source	Elsevier; Medline; PMC
abstract	In order to evaluate sheep as experimental model to test the efficacy of HoBi-like pestivirus vaccines for cattle, 10 sheep at different stages of pregnancy (30 or 50 days) were experimentally infected with the Italian prototype isolate Italy-1/10-1. Irrespective of the stage of pregnancy, virus inoculation resulted in reproductive failures, consisting of abortion, stillbirths or birth of weak or persistently infected (PI) lambs. Aborted fetuses, stillborn and dead lambs displayed extensive histopathological changes, consisting of hemorrhages, congestion and mononuclear infiltration in major organs. Pestiviral antigens were detected by immunohistochemistry in most tissues with remarkable signals in lungs and kidneys. PI lambs were constantly viremic, shed the virus through the nasal secretions and feces and, in all cases but one, did not have detectable HoBi-like pestivirus antibodies before the assumption of colostrum. The single seropositive infected lamb showed low-titer viremia and viral shedding that ceased only several weeks after the 3-month observation period. The study proves that sheep are susceptible to the reproduction failures caused by HoBi-like pestivirus infection and can serve as a suitable model for the evaluation of the fetal protection induced by homologous experimental vaccines.
has issue date	2015-08-05(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2015.05.011
bibo:pmid	26013415
has license	no-cc
sha1sum (hex)	5931c8a2146123a830e21a82deee51ab4dab54e3
schema:url	https://doi.org/10.1016/j.vetmic.2015.05.011
resource representing a document's title	HoBi-like pestivirus experimental infection in pregnant ewes: Reproductive disorders and generation of persistently infected lambs
has PubMed Central identifier	PMC7172706
has PubMed identifier	26013415
schema:publication	Vet Microbiol
resource representing a document's body	covid:5931c8a2146123a830e21a82deee51ab4dab54e3#body_text
is schema:about of	named entity 'hemorrhages' named entity 'cattle' named entity 'Italian' named entity 'pestivirus' named entity 'vaccines' named entity 'dead' named entity 'detectable' named entity 'immunohistochemistry' named entity 'weeks' named entity 'seropositive' named entity 'sheep' named entity 'antibodies' named entity 'extensive' named entity 'pestivirus' named entity 'lungs' named entity 'viremic' named entity 'fetal' named entity 'viremia' named entity 'antibodies' named entity 'histopathological' named entity 'pestivirus' named entity 'stillborn' named entity 'pestivirus' named entity 'vaccines' named entity 'kidneys' named entity 'BVDV' named entity '1:2' named entity 'ovine' named entity 'H&E' named entity 'virus' named entity 'spleen' named entity 'optical density' named entity 'cattle' named entity 'RNA' named entity 'endemic' named entity 'nested PCR' named entity 'Italy' named entity 'Milan' named entity 'sheep' named entity 'infection' named entity 'seropositive' named entity 'pestivirus' named entity 'infection' named entity 'PCR' named entity 'ovine' named entity 'NS3' named entity 'cattle' named entity 'vaccines' named entity 'alveolar capillaries' named entity 'viruses' named entity 'pestivirus' named entity 'RNA' named entity 'virus' named entity 'pestivirus' named entity 'monoclonal antibodies' named entity 'BVDV' named entity 'Viral' named entity 'RNA' named entity 'Kenya' named entity 'pestivirus' named entity 'clinical sign' named entity 'centrifugation' named entity 'Nanyuki' named entity 'fetal bovine serum' named entity 'virus shedding' named entity 'Fetuses' named entity 'viruses' named entity 'fluorescein isothiocyanate' named entity 'gestation'

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