About: Tissue-specific responses of antioxidant pathways to poor hygiene conditions in growing pigs divergently selected for feed efficiency

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About: Tissue-specific responses of antioxidant pathways to poor hygiene conditions in growing pigs divergently selected for feed efficiency Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tissue-specific responses of antioxidant pathways to poor hygiene conditions in growing pigs divergently selected for feed efficiency
Creator	Gondret, F Le Floc'h, N Merlot, E Perruchot, M-H Sierżant, K
source	Medline; PMC
abstract	BACKGROUND: Poor hygiene of housing induces a systemic inflammatory response. Because inflammation and oxidative stress are processes that can sustain each other, the ways pigs are able to activate their antioxidant defenses are critical for production performance and health during periods when the immune system is solicited. Selection for production performance can also influence reactive oxygen species (ROS) production and expression levels of genes involved in cellular response to oxidative stress in different tissues. To establish the extent by which poor hygiene and selection for feed efficiency affected redox status, pigs divergently selected for residual feed intake (RFI) were housed in poor or good hygiene during 6 weeks. At the end, blood was collected in all pigs, and half of them were killed for tissue sampling. The remaining pigs were reared in good hygiene conditions during a recovery period of 7–8 weeks. RESULTS: At week 6, poor hygiene was associated with a lower total antioxidant capacity assessed by plasma ferric reducing ability in all pigs, and with greater plasma levels of hydrogen peroxides in the high RFI pigs (less efficient). Adipose tissue of high RFI pigs exhibited higher activities of catalase and glutathione reductase, and greater thiobarbituric acid reactive substances (TBARS) concentrations when compared with the low RFI pigs (more efficient). Poor hygiene conditions activated the antioxidant enzymes activities (glutathione reductase, superoxide dismutase and catalase) in adipose tissue of both lines, but led to higher ROS production by mature adipocytes isolated from the high RFI pigs only. In liver and muscle, there were only minor changes in antioxidant molecules due to genetics and hygiene conditions. After the resilience period, adipose tissue of pigs previously challenged by poor hygiene maintained higher antioxidant enzyme activities, and for the high RFI line, displayed higher TBARS concentrations. CONCLUSIONS: Pigs selected for improved feed efficiency showed a lower susceptibility to oxidative stress induced by poor hygiene conditions. This could led to a lower inflammatory response and less impaired growth when these pigs are facing sanitary challenges during the production period.
has issue date	2019-10-16(xsd:dateTime)
bibo:doi	10.1186/s12917-019-2107-2
bibo:pmid	31619228
has license	cc-by
sha1sum (hex)	5a7eaaf283f1005f17f029f26a9ec33eebe566bc
schema:url	https://doi.org/10.1186/s12917-019-2107-2
resource representing a document's title	Tissue-specific responses of antioxidant pathways to poor hygiene conditions in growing pigs divergently selected for feed efficiency
has PubMed Central identifier	PMC6794813
has PubMed identifier	31619228
schema:publication	BMC Vet Res
resource representing a document's body	covid:5a7eaaf283f1005f17f029f26a9ec33eebe566bc#body_text
is schema:about of	named entity 'TISSUE' named entity 'ways' named entity 'sustain' named entity 'induces' named entity 'Selection' named entity 'periods' named entity 'hygiene' named entity 'conditions' named entity 'HYGIENE' named entity 'TISSUE SAMPLING' named entity 'DIFFERENT' named entity 'GENES' named entity 'INFLUENCE' named entity 'SOLICITED' named entity 'BACKGROUND' named entity 'SUSTAIN' named entity 'ACTIVATE' named entity 'REACTIVE OXYGEN SPECIES' named entity 'INFLAMMATORY RESPONSE' named entity 'TISSUES' named entity 'PERFORMANCE' named entity 'COLLECTED' named entity 'POOR' named entity 'RECOVERY PERIOD' named entity 'REMAINING' named entity 'FEED EFFICIENCY' named entity 'POOR HYGIENE' named entity 'INFLAMMATION' named entity 'INVOLVED' named entity '6 WEEKS' named entity 'CONDITIONS' named entity 'SELECTION' named entity 'PRODUCTION' named entity 'PIGS' named entity 'THEIR' covid:arg/5a7eaaf283f1005f17f029f26a9ec33eebe566bc named entity 'IMMUNE SYSTEM' named entity 'CELLULAR RESPONSE TO OXIDATIVE STRESS' named entity 'ANTIOXIDANT' named entity 'SPECIFIC' named entity 'RESPONSES' named entity 'POOR HYGIENE' named entity 'GROWING PIGS' named entity 'SELECTED' named entity 'FEED EFFICIENCY' named entity 'CRITICAL' named entity 'EXPRESSION' named entity 'GOOD' named entity 'AFFECTED' named entity 'HALF' named entity 'HOUSING' named entity 'OXIDATIVE STRESS' named entity 'AT THE END' named entity 'SYSTEMIC' named entity 'RESIDUAL FEED INTAKE' named entity 'BLOOD' named entity '7-8' named entity 'KILLED' named entity 'ANTIOXIDANT' named entity 'REDOX' named entity 'LEVELS' named entity '8 WEEKS' named entity 'PROCESSES' named entity 'EXTENT' named entity 'CONDITIONS' named entity 'PATHWAYS' named entity 'STATUS' named entity 'HEALTH' named entity 'PERIODS' named entity 'ESTABLISH' named entity 'HOUSED' named entity 'critical' named entity 'response' named entity 'sampling' named entity 'hygiene' named entity 'oxidative stress' named entity 'Poor hygiene'

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