About: Do viruses subvert cholesterol homeostasis to induce host cubic membranes?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Do viruses subvert cholesterol homeostasis to induce host cubic membranes?
Creator	Deng, Yuru Almsherqi, Zakaria Kohlwein, Sepp Ng, Mary
Source	Elsevier; Medline; PMC
abstract	Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein–protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the ‘virus factory’ and offer new avenues to combat viral infections.
has issue date	2010-07-31(xsd:dateTime)
bibo:doi	10.1016/j.tcb.2010.04.001
bibo:pmid	20434915
has license	els-covid
sha1sum (hex)	5d453838f09a5482566b8485ec4a6bc4e3f7df02
schema:url	https://doi.org/10.1016/j.tcb.2010.04.001
resource representing a document's title	Do viruses subvert cholesterol homeostasis to induce host cubic membranes?
has PubMed Central identifier	PMC7127466
has PubMed identifier	20434915
schema:publication	Trends in Cell Biology
resource representing a document's body	covid:5d453838f09a5482566b8485ec4a6bc4e3f7df02#body_text
is schema:about of	named entity 'MEMBRANES' named entity 'INDUCE' named entity 'CUBIC' named entity 'HOST' named entity 'CHOLESTEROL HOMEOSTASIS' named entity 'VIRUSES' named entity 'proteolytic cleavage' named entity 'virus entry' named entity 'autophagy' named entity 'TEM' named entity 'molecular mechanisms' named entity 'HMG-CoA reductase' named entity 'membrane microdomains' named entity 'virus' named entity 'neoplastic diseases' named entity 'animals to humans' named entity 'homeostasis' named entity 'SREBP' named entity 'enzyme activity' named entity 'viperin' named entity 'pharmacological intervention' named entity 'electron microscopic' named entity 'virus factory' named entity 'enveloped viruses' named entity 'phospholipids' named entity 'ROS' named entity 'endoplasmic reticulum' named entity 'cytoplasm' named entity 'Flaviviridae' named entity 'morphological' named entity 'Golgi' named entity 'production of cholesterol' named entity 'genome' named entity 'lipids' named entity 'viruses' named entity 'oxidative stress' named entity 'enzyme' named entity 'electron tomography' named entity 'biosynthesis' named entity 'virus' named entity 'morphologically' named entity 'cholesterol synthesis' named entity 'transcription factors' named entity 'lipid bilayer' named entity 'lattice' named entity 'sterol' named entity 'intracellular membrane' named entity 'lipid' named entity 'protein-protein interactions' named entity 'viruses' named entity 'RNA' named entity 'membrane proteins' named entity 'viral replication' named entity 'cellular components' named entity 'Dengue' named entity 'organism' named entity 'HMG-CoA reductase inhibitors' named entity 'cholesterol' named entity 'point mutations' named entity 'non-lamellar phases' named entity 'protein' named entity 'protein' named entity 'cholesterol synthesis' named entity 'polyprotein' named entity 'lysosomal degradation' named entity 'defense mechanism' named entity 'virus' named entity 'life cycle' named entity 'cellular metabolism' named entity 'HMG-CoA reductase' named entity 'phenotypic' named entity 'protein-protein interactions' named entity 'host cells' named entity 'viral infection' named entity 'dimerization' named entity 'budding process' named entity 'viral replication' named entity 'cytoplasmic'

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