About: Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus

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About: Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus
Creator	Taguchi, Fumihiro Watanabe, Rie Sawicki, Stanley
Source	Elsevier; Medline; PMC
abstract	Abstract A highly neurovirulent mouse hepatitis virus (MHV) JHMV strain (wt) with receptor (MHVR)-independent infection activity and its low-virulent mutant srr7 without such activity were found to attach to MHVR-negative, non-permissive BHK cells. To identify the molecule that interacts with JHMV, we focused on heparan sulfate (HS) since it works as a receptor of a mutant MHV-rec1 that infects in an MHVR-independent fashion. The present study indicates that HS interacts with both wt JHMV and srr7 but it does not function as an entry receptor as it apparently does for MHV-rec1. Furthermore, HS failed to serve as an entry receptor in the MHVR-independent infection of wt JHMV, indicating that HS is not a host factor that wt JHMV utilizes in an MHVR-independent infection.
has issue date	2007-09-15(xsd:dateTime)
bibo:doi	10.1016/j.virol.2007.06.034
bibo:pmid	17692355
has license	els-covid
sha1sum (hex)	5d71dc4034a9e0db9fbb4e9197668df2ecefdcfa
schema:url	https://doi.org/10.1016/j.virol.2007.06.034
resource representing a document's title	Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus
has PubMed Central identifier	PMC7103320
has PubMed identifier	17692355
schema:publication	Virology
resource representing a document's body	covid:5d71dc4034a9e0db9fbb4e9197668df2ecefdcfa#body_text
is schema:about of	named entity 'BINDING' named entity 'INDEPENDENT' named entity 'neurovirulent' named entity 'indicating' named entity 'failed' named entity 'IS A' named entity 'VIRULENT' named entity 'MHVR' named entity 'HOST FACTOR' named entity 'INDEPENDENT' named entity 'TO IDENTIFY' named entity 'DOES' named entity 'FOCUSED' named entity 'ITS' covid:arg/5d71dc4034a9e0db9fbb4e9197668df2ecefdcfa named entity 'MOLECULE' named entity 'BUT' named entity 'CEACAM1' named entity 'INFECTION' named entity 'HEPARAN SULFATE' named entity 'MURINE CORONAVIRUS' named entity 'BUT' named entity 'RECEPTOR' named entity 'WORKS' named entity 'ACTIVITY' named entity 'STRAIN' named entity 'HIGHLY' named entity 'RECEPTOR' named entity 'MUTANT' named entity 'APPARENTLY' named entity 'ENTRY' named entity 'LOW' named entity 'MOUSE HEPATITIS VIRUS' named entity 'INFECTS' named entity 'FASHION' named entity 'REC1' named entity 'ATTACH' named entity 'INFECTION' named entity 'MOLECULE' named entity 'INDICATING' named entity 'FOUND' named entity 'HEPARAN SULFATE' named entity 'FUNCTION' named entity 'STUDY' named entity 'NON-' named entity 'BHK CELLS' named entity 'TO SERVE AS' named entity 'NEGATIVE' named entity 'FAILED' named entity 'DOES NOT' named entity 'PRESENT' named entity 'mutant' named entity 'infects' named entity 'interacts' named entity 'neurovirulent' named entity 'receptor' named entity 'receptor' named entity 'virulent' named entity 'infection' named entity 'murine coronavirus' named entity 'FITC' named entity 'cell surface' named entity 'mutation' named entity 'protein' named entity 'infectivity' named entity 'heparin' named entity '5.5' named entity 'neurotropic' named entity 'virus' named entity 'cell surface' named entity 'infection' named entity 'virus' named entity 'infection' named entity 'BHK' named entity 'Becton Dickinson' named entity 'BHK' named entity 'molecule' named entity 'St. Louis' named entity 'cell surface'

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