About: Coumarin as a structural component of substrates and probes for serine and cysteine proteases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coumarin as a structural component of substrates and probes for serine and cysteine proteases
Creator	Bartz, Ulrike Breidenbach, Julian Gütschow, Michael
source	Elsevier; Medline; PMC
abstract	Coumarins represent well-established structures to introduce fluorescence into tool compounds for biochemical investigations. They are valued for their small size, chemical stability and accessibility as well as their tunable photochemical properties. As components of fluorophore/quencher pairs or FRET donor/acceptor pairs, coumarins have frequently been applied in substrate mapping approaches for serine and cysteine proteases. This review also focuses on the incorporation of coumarins into the side chain of amino acids and the exploitation of the resulting fluorescent amino acids for the positional profiling of protease substrates. The protease-inhibiting properties of certain coumarin derivatives and the utilization of coumarin moieties to assemble activity-based probes for serine and cysteine protease are discussed as well.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1016/j.bbapap.2020.140445
bibo:pmid	32405284
has license	no-cc
sha1sum (hex)	5f620fc799356ceb155582612d3d147215b49c03
schema:url	https://doi.org/10.1016/j.bbapap.2020.140445
resource representing a document's title	Coumarin as a structural component of substrates and probes for serine and cysteine proteases
has PubMed Central identifier	PMC7219385
has PubMed identifier	32405284
schema:publication	Biochim Biophys Acta Proteins Proteom
resource representing a document's body	covid:5f620fc799356ceb155582612d3d147215b49c03#body_text
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