About: The human coronavirus HCoV-229E S-protein structure and receptor binding

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The human coronavirus HCoV-229E S-protein structure and receptor binding Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The human coronavirus HCoV-229E S-protein structure and receptor binding
Creator	Desforges, Marc Benlekbir, Samir Li, Zhijie Zhou, Dongxia Talbot, Pierre Wong, Alan Rini, James Rubinstein, John Ca Tomlinson, Aidan
Source	Medline; PMC
abstract	The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune evasion and the cross-species transmission of 229E and related coronaviruses. We also find that the 229E S-protein can expose a portion of its helical core to solvent. This is undoubtedly facilitated by hydrophilic subunit interfaces that we show are conserved among coronaviruses. These interfaces likely play a role in the S-protein conformational changes associated with membrane fusion.
has issue date	2019-10-25(xsd:dateTime)
bibo:doi	10.7554/elife.51230
bibo:pmid	31650956
has license	cc-by
sha1sum (hex)	6091444b4f7495b1b4cb0c72b6f30da73ccf867d
schema:url	https://doi.org/10.7554/elife.51230
resource representing a document's title	The human coronavirus HCoV-229E S-protein structure and receptor binding
has PubMed Central identifier	PMC6970540
has PubMed identifier	31650956
schema:publication	eLife
resource representing a document's body	covid:6091444b4f7495b1b4cb0c72b6f30da73ccf867d#body_text
is schema:about of	named entity 'structure' named entity 'HOST CELL' named entity 'CLASS III' named entity 'MEMBRANE FUSION' named entity 'IMMUNE EVASION' named entity 'ROLE' named entity 'BUT' named entity 'SEQUENCE VARIATION' named entity 'EXPOSE' named entity 'HCOV-229E' named entity 'HELICAL' named entity 'THESE' named entity 'HAPN' named entity 'PORTION' named entity 'SUBUNIT' named entity 'UNDERSTOOD' named entity 'AMINOPEPTIDASE N' named entity 'MAINTAINED' named entity 'S-PROTEIN' named entity 'INSIGHT' named entity 'X-RAY' named entity 'STRUCTURES' named entity 'PROTEIN STRUCTURE' named entity 'COMMON' named entity 'RESULTS' named entity 'REPORTED' named entity 'S-PROTEIN' named entity 'RECEPTOR BINDING' named entity 'HUMAN CORONAVIRUS' named entity 'HYDROPHILIC' named entity 'CELL MEMBRANES' named entity 'COMPLEX' named entity 'PLASTICITY' named entity 'CRYSTAL' named entity 'HOW' named entity 'DOMAIN' named entity '229E' named entity 'PLAY' named entity 'VIRAL AND' named entity 'SPECIFICITY' named entity 'ITS' named entity 'FUSION' named entity 'INTERACTIONS' named entity 'ASSOCIATED WITH' named entity 'CONSERVED' named entity 'LIKELY' named entity 'PROTEIN ' named entity 'LOOP' named entity 'EXTENSIVE' named entity 'HUMAN' named entity 'MEDIATES' named entity 'ELECTRON CRYOMICROSCOPY' named entity 'PROTEIN FUNCTION' named entity 'PROVIDE' named entity 'HCOV-229E' named entity 'RECEPTOR BINDING' named entity 'PROTEIN CAN' named entity 'RBD' named entity 'CORE' named entity 'CORONAVIRUSES' named entity 'CORONAVIRUS' named entity 'RELATED' named entity 'STRUCTURE' named entity 'TRANSMISSION' named entity 'PERIPHERAL' named entity 'SOLVENT' named entity 'CHANGES' covid:arg/6091444b4f7495b1b4cb0c72b6f30da73ccf867d named entity 'membrane fusion' named entity 'fusion' named entity 'loop' named entity 'crystal structures' named entity 'RBD'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software