About: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections

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About: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections
Creator	Zhan, Bin Briggs, Neima Jones, Kathryn Hotez, Peter Beaumier, Coreen Bottazzi, Maria Keegan, Brian
source	Medline; PMC
abstract	ASCARIS LUMBRICOIDES: The Sabin Vaccine Institute Product Development Partnership is developing a Pan-anthelmintic vaccine that simultaneously targets the major soil-transmitted nematode infections, in other words, ascariasis, trichuriasis and hookworm infection. The approach builds off the current bivalent Human Hookworm Vaccine now in clinical development and would ultimately add both a larval Ascaris lumbricoides antigen and an adult-stage Trichuris trichiura antigen from the parasite stichosome. Each selected antigen would partially reproduce the protective immunity afforded by UV-attenuated Ascaris eggs and Trichuris stichosome extracts, respectively. Final antigen selection will apply a ranking system that includes the evaluation of expression yields and solubility, feasibility of process development and the absence of circulating antigen-specific IgE among populations living in helminth-endemic regions. Here we describe a five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.
has issue date	2014-01-06(xsd:dateTime)
bibo:doi	10.1586/14760584.2014.872035
bibo:pmid	24392641
has license	cc-by-nc
sha1sum (hex)	61b8415c8659a58c24af2b8a2456bed96b61b609
schema:url	https://doi.org/10.1586/14760584.2014.872035
resource representing a document's title	Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections
has PubMed Central identifier	PMC3934375
has PubMed identifier	24392641
schema:publication	Expert Rev Vaccines
resource representing a document's body	covid:61b8415c8659a58c24af2b8a2456bed96b61b609#body_text
is schema:about of	named entity 'SOIL' named entity 'ADULT' named entity 'ENDEMIC' named entity 'DISCOVERY' named entity 'EXTRACTS' named entity 'SCALE' named entity 'HUMAN' named entity 'ATTENUATED' named entity 'VACCINE' named entity 'SPECIFIC IGE' named entity 'LEAD' named entity 'PARTIALLY' named entity 'PRACTICES' named entity 'SELECTION' named entity 'ADD' named entity 'SOLUBILITY' named entity 'MAJOR' named entity 'TRICHURIASIS' named entity 'PARASITE' named entity 'ASCARIS LUMBRICOIDES' named entity 'CLINICAL TESTING' named entity 'ANTHELMINTIC' named entity 'WORDS' named entity 'clinical development' named entity 'ultimately' named entity 'antigen' named entity 'current' named entity 'TRANSMITTED' named entity 'PRECLINICAL' named entity 'TRICHURIS' named entity 'HOOKWORM' named entity 'DEVELOPMENT' named entity 'DESCRIBE' named entity 'STAGE' named entity 'ANTHELMINTIC' named entity 'CIRCULATING' named entity 'TOXICOLOGY' named entity 'APPLY' named entity 'EVALUATION' named entity 'HOOKWORM INFECTION' named entity 'LIVING' named entity 'YEAR' named entity 'LABORATORY' named entity 'VACCINE' named entity 'ADVANCING' named entity 'NEMATODE INFECTIONS' named entity 'PRODUCT DEVELOPMENT' named entity 'NEMATODE INFECTIONS' named entity 'REGIONS' named entity 'TRICHURIS TRICHIURA' named entity 'ASCARIASIS' named entity 'SYSTEM' named entity 'PHASE 1' named entity 'INCLUDES' named entity 'HELMINTH' named entity 'POPULATIONS' named entity 'PARTNERSHIP' named entity 'CURRENT' named entity 'RANKING' named entity 'DEVELOPING' named entity 'TRANSMITTED' named entity 'LARVAL' named entity 'REPRODUCE' named entity 'GOOD' named entity 'ASCARIS' named entity 'FINAL' named entity 'MANUFACTURE' named entity 'EGGS' named entity 'HERE' named entity 'INSTITUTE' named entity 'PROCESS' named entity 'SELECTED' named entity 'APPROACH' named entity 'EXPRESSION' named entity 'FEASIBILITY'

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