About: A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses

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About: A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
Creator	Zheng, Bo-Jian Jin, Dong-Yan Yuen, Kwok-Yung Zhou, Jie Leung, Ho-Chuen Chu, Hin Lin, Yong-Ping Fai, Ng Liu, Dabin Zhang, Ke Zhao, Hanjun Chan, Chung-Sing Kwok-Man, Vincent Poon, Zhang, Jin-Xia
Source	Medline; PMC
abstract	A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.
has issue date	2016-02-25(xsd:dateTime)
bibo:doi	10.1038/srep22008
bibo:pmid	26911565
has license	cc-by
sha1sum (hex)	61c8af64ef0a95e3f6dfc71ced3f94c2768e23d2
schema:url	https://doi.org/10.1038/srep22008
resource representing a document's title	A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
has PubMed Central identifier	PMC4766503
has PubMed identifier	26911565
schema:publication	Sci Rep
resource representing a document's body	covid:61c8af64ef0a95e3f6dfc71ced3f94c2768e23d2#body_text
is schema:about of	named entity 'BROAD' named entity 'peptides' named entity 'antiviral' named entity 'antiviral' named entity 'H1N1' named entity 'binding' named entity 'surface' named entity 'composition' named entity 'basic' named entity 'NOVEL' named entity 'ACTIVITIES' named entity 'H3N2' named entity 'H5N1' named entity 'MERS-COV' named entity 'RELEASE' named entity 'ACIDIFICATION' named entity 'ANTIVIRAL ACTIVITY' named entity 'GLYCOPROTEINS' named entity 'EFFECTS' named entity 'BINDING' named entity 'SARS-COV' named entity 'MEMBRANE FUSION' named entity 'PEPTIDE' named entity 'COMPOSITION' named entity 'ENTERED' named entity 'IN VITRO' named entity 'COMBAT' named entity 'MULTIPLE' named entity 'FOUND' named entity 'HIGH' named entity 'BLOCKED' named entity 'NEW' named entity 'ENDOCYTOSIS' named entity 'ITS' named entity 'SPECTRUM' named entity 'DEVELOPING' named entity 'SUBSEQUENT' named entity 'AFFINITY' named entity 'STUDY' named entity 'H1N1' named entity 'SPECTRUM' named entity 'DERIVED' named entity 'ABUNDANCE' named entity 'ANTIVIRAL' named entity 'VIRAL PARTICLES' named entity 'SHORT' named entity 'ANTIVIRAL' named entity 'VIRUSES' named entity 'PROPHYLACTIC' named entity 'PEPTIDES' named entity 'IN VIVO' named entity 'H7N9' named entity 'AVENUE' named entity 'TESTED' named entity 'DEFENSIN' named entity 'SAFE' named entity 'OPEN' named entity 'MULTIPLE' named entity 'INCLUDING' named entity 'BROAD' named entity 'MOUSE' named entity 'NEEDED' named entity 'DEFENSINS' named entity 'VIRAL' named entity 'RESPIRATORY VIRUSES' named entity 'BASIC AMINO ACIDS' named entity 'RESPIRATORY VIRUSES'

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