About: Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment

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About: Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment
Creator	Collawnt, James Davis, Cynthia Hopkins, Colin Odorizzi, C Trowbridge, Ian Xue, Luzheng
Source	PMC
abstract	Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis of Ii-transferrin receptor (TR) chimera trafficking, we have identified sorting signals in the Ii cytoplasmic tail and transmembrane region that mediate this process. Two non-tyrosine-based sorting signals in the Ii cytoplasmic tail were identified that mediate localization to plasma membrane clathrin-coated pits and promote rapid endocytosis. Leu7 and Ile8 were required for the activity of the signal most distal to the cell membrane whereas Pro15 Met16 Leu17 were important for the membrane-proximal signal. The same or overlapping non- tyrosine-based sorting signals are essential for delivery of Ii-TR chimeras, either by an intracellular route or via the plasma membrane, to an endocytic compartment where they are rapidly degraded. The Ii transmembrane region is also required for efficient delivery to this endocytic processing compartment and contains a signal distinct from the Ii cytoplasmic tail. More than 80% of the Ii-TR chimera containing the Ii cytoplasmic tail and transmembrane region is delivered directly to the endocytic pathway by an intracellular route, implying that the Ii sorting signals are efficiently recognized by sorting machinery located in the trans-Golgi.
has issue date	1994-07-02(xsd:dateTime)
bibo:pmid	8034737
has license	cc-by-nc-sa
sha1sum (hex)	6220d2580a3a4a5c86ea58944be947b5d4c0bc0b
resource representing a document's title	Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment
has PubMed Central identifier	PMC2200027
has PubMed identifier	8034737
schema:publication	J Cell Biol
resource representing a document's body	covid:6220d2580a3a4a5c86ea58944be947b5d4c0bc0b#body_text
is schema:about of	named entity 'TRANSFERRIN RECEPTOR' named entity 'IMPORTANT' named entity 'INVARIANT CHAIN' named entity 'THE CELL' named entity 'SIGNAL' named entity 'REQUIRED' named entity 'PITS' named entity 'COMPARTMENT' named entity 'DETERMINED BY' named entity 'MEMBRANE' named entity 'NON-' named entity 'SORTING' named entity 'MHC CLASS II' named entity 'PROXIMAL' named entity 'LOCALIZATION' named entity 'promote' named entity 'localization' named entity 'signals' named entity 'Ile' named entity 'endocytosis' named entity 'Signals' named entity 'Trafficking' named entity 'MHC Class II' named entity 'SIGNALS' named entity 'COMPARTMENT' named entity 'ENDOCYTOSIS' named entity 'INVARIANT CHAIN' named entity 'TARGETING' named entity 'MET16' named entity 'PROMOTE' named entity 'PLASMA MEMBRANE' named entity 'WHERE' named entity 'SIGNALS' named entity 'SORTING' named entity 'TRAFFICKING' named entity 'PROCESSING' named entity 'DETERMINE' named entity 'CYTOPLASMIC' named entity 'MHC CLASS II' named entity 'TAFT' named entity 'CELL MEMBRANE' named entity 'PROCESSED' named entity 'TRANSMEMBRANE REGION' named entity 'ANTIGEN' named entity 'PROCESS' named entity 'TRAFFICKING' named entity 'MOLECULES' named entity 'BASED' named entity 'ANALYSIS' named entity 'ACTIVITY' named entity 'CYTOPLASMIC TAIL' named entity 'DISTAL TO' named entity 'TYROSINE' named entity 'ILE' named entity 'IDENTIFIED' named entity 'TRANSMEMBRANE REGION' named entity 'LEU' named entity 'ENCOUNTER' named entity 'RAPID' named entity 'MEDIATE' named entity 'CHIMERA' named entity 'HAVE' covid:arg/6220d2580a3a4a5c86ea58944be947b5d4c0bc0b named entity 'rapid' named entity 'Targeting' named entity 'wild-type' named entity 'antibody' named entity 'trans-Golgi' named entity 'tyrosine' named entity 'serum' named entity 'tyrosine' named entity 'endosome' named entity 'external domain' named entity 'retroviral' named entity 'methionine' named entity 'glycine' named entity 'coated vesicles' named entity 'chimeric'

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