About: Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus

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About: Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus
Creator	Reyes-Leyva, Julio Hernández, Jesús Martínez-Lara, Atalo Pérez-Torres, Armando Ramírez-Mendoza, Humberto Saavedra-Montañez, Manuel Sánchez-Betancourt, Ivan De La Luz-Armendáriz, Jazmín Jasso-Escutia, Miguel Rivera-Benitez, José
source	Elsevier; Medline; PMC
abstract	Porcine rubulavirus (PorPV) and swine influenza virus infection causes respiratory disease in pigs. PorPV persistent infection could facilitate the establishment of secondary infections. The aim of this study was to analyse the pathogenicity of classic swine H1N1 influenza virus (swH1N1) in growing pigs persistently infected with porcine rubulavirus. Conventional six-week-old pigs were intranasally inoculated with PorPV, swH1N1, or PorPV/swH1N1. A mock-infected group was included. The co-infection with swH1N1 was at 44 days post-infection (DPI), right after clinical signs of PorPV infection had stopped. The pigs of the co-infection group presented an increase of clinical signs compared to the simple infection groups. In all infected groups, the most recurrent lung lesion was hyperplasia of the bronchiolar-associated lymphoid tissue and interstitial pneumonia. By means of immunohistochemical evaluation it was possible to demonstrate the presence of the two viral agents infecting simultaneously the bronchiolar epithelium. Viral excretion of PorPV in nasal and oral fluid was recorded at 28 and 52 DPI, respectively. PorPV persisted in several samples from respiratory tissues (RT), secondary lymphoid organs (SLO), and bronchoalveolar lavage fluid (BALF). For swH1N1, the viral excretion in nasal fluids was significantly higher in single-infected swH1N1 pigs than in the co-infected group. However, the co-infection group exhibited an increase in the presence of swH1N1 in RT, SLO, and BALF at two days after co-infection. In conclusion, the results obtained confirm an increase in the clinical signs of infection, and PorPV was observed to impact the spread of swH1N1 in analysed tissues in the early stage of co-infection, although viral shedding was not enhanced. In the present study, the interaction of swH1N1 infection is demonstrated in pigs persistently infected with PorPV.
has issue date	2016-02-29(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2016.01.005
bibo:pmid	26854342
has license	no-cc
sha1sum (hex)	624006b37d3cc62c341bfb1866136940078a14e1
schema:url	https://doi.org/10.1016/j.vetmic.2016.01.005
resource representing a document's title	Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus
has PubMed Central identifier	PMC7117528
has PubMed identifier	26854342
schema:publication	Vet Microbiol
resource representing a document's body	covid:624006b37d3cc62c341bfb1866136940078a14e1#body_text
is schema:about of	named entity 'H1N1 INFLUENZA' named entity 'inoculated' named entity 'For' named entity 'DPI' named entity 'respiratory' named entity 'hyperplasia' named entity 'PORCINE RUBULAVIRUS' named entity 'CAUSES' named entity 'SIMPLE INFECTION' named entity 'SECONDARY LYMPHOID ORGANS' named entity 'GROWING PIGS' named entity 'SECONDARY INFECTIONS' named entity 'STOPPED' named entity 'INTERACTION' named entity 'HYPERPLASIA' named entity 'POSSIBLE' named entity 'RECURRENT' named entity 'OLD' named entity 'STUDY' named entity 'OBTAINED' named entity 'BRONCHIOLAR EPITHELIUM' named entity 'RESPIRATORY DISEASE' named entity 'PORCINE RUBULAVIRUS' named entity 'EVALUATION' named entity 'CO-INFECTION' named entity 'CLASSIC' named entity 'RIGHT' named entity 'GROUP' named entity 'DAYS' named entity 'POST' named entity 'PATHOGENICITY' named entity 'OBSERVED' named entity 'VIRUS INFECTION' named entity 'EXCRETION' named entity 'NASAL' named entity 'MOCK' named entity 'PRESENTED' named entity 'PERSISTENT INFECTION' named entity 'HIGHER' named entity 'EARLY STAGE' named entity 'SWINE INFLUENZA VIRUS' named entity 'INCLUDED' named entity 'SWINE' named entity 'CLASSIC' named entity 'WEEK' named entity 'H1N1 INFLUENZA' named entity 'PRESENT' named entity 'LUNG LESION' named entity 'INFECTED' named entity 'RECORDED' named entity 'COMPARED' named entity 'FLUIDS' named entity 'CO-INFECTION' named entity 'SAMPLES' named entity 'INFLUENZA VIRUS' named entity 'RESPIRATORY' named entity 'SINGLE' named entity 'CONVENTIONAL' named entity 'MEANS' named entity 'GROUPS' named entity 'INFECTION GROUP' named entity 'INTERSTITIAL PNEUMONIA' named entity 'VIRAL SHEDDING' named entity 'INFECTION' named entity 'PIGS' named entity 'SWINE' named entity 'ORAL FLUID' named entity 'COINFECTION' named entity 'LYMPHOID TISSUE' named entity 'TISSUES' named entity 'VIRAL' named entity 'BRONCHOALVEOLAR LAVAGE FLUID'

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